关键词: DNA damage and repair Intraductal carcinoma of the prostate MED12 MYC NCOR2 PTEN RB1 SChLAP1 TMPRSS2-ERG fusion TP53 molecular characteristics prostate acinar adenocarcinoma targeted therapy

Mesh : Male Humans Carcinoma, Intraductal, Noninfiltrating / pathology Prostate / pathology Prostatic Neoplasms / diagnosis genetics therapy Prognosis

来  源:   DOI:10.1002/cam4.6939   PDF(Pubmed)

Abstract:
Intraductal carcinoma of the prostate (IDC-P) is an aggressive subtype of prostate cancer characterized by the growth of tumor cells within the prostate ducts. It is often found alongside invasive carcinoma and is associated with poor prognosis. Understanding the molecular mechanisms driving IDC-P is crucial for improved diagnosis, prognosis, and treatment strategies. This review summarizes the molecular characteristics of IDC-P and their prognostic indications, comparing them to conventional prostate acinar adenocarcinoma, to gain insights into its unique behavior and identify potential therapeutic targets.
摘要:
前列腺导管内癌(IDC-P)是一种侵袭性前列腺癌亚型,其特征在于前列腺导管内肿瘤细胞的生长。它通常与浸润性癌一起发现,并与不良预后有关。了解驱动IDC-P的分子机制对于改善诊断至关重要。预后,和治疗策略。本文就IDC-P的分子特征及其预后指征作一综述。将它们与常规前列腺腺泡腺癌进行比较,以深入了解其独特的行为并确定潜在的治疗目标。
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