PDF(Pubmed)
Abstract：
BACKGROUND: Fusobacterium nucleatum (F. nucleatum) belongs to the genus Fusobacterium, which is a gram-negative obligate anaerobic bacterium. Bacteremia associated with F. nucleatum is a serious complication, which is not common in clinic, especially when it is combined with other intracranial pathogenic microorganism infection. We reported for the first time a case of F. nucleatum bacteremia combined with intracranial Porphyromonas gingivalis (P. gingivalis) and herpes simplex virus type 1(HSV-1) infection.
METHODS: A 60-year-old woman was admitted to our hospital with a headache for a week that worsened for 2 days. Combined with history, physical signs and examination, it was characterized as ischemic cerebrovascular disease (ICVD). F. nucleatum was detected in blood by matrix-assisted laser desorption/ionization time-offight mass spectrometry (MALDI-TOF-MS). Meanwhile, P. gingivalis and HSV-1 in cerebrospinal fluid (CSF) were identified by metagenome next generation sequencing (mNGS). After a quick diagnosis and a combination of antibiotics and antiviral treatment, the patient recovered and was discharged.
CONCLUSIONS: To our knowledge, this is the first report of intracranial P. gingivalis and HSV-1 infection combined with F. nucleatum bacteremia.
METHODS: A 60-year-old woman was admitted to our hospital with a headache for a week that worsened for 2 days. Combined with history, physical signs and examination, it was characterized as ischemic cerebrovascular disease (ICVD). F. nucleatum was detected in blood by matrix-assisted laser desorption/ionization time-offight mass spectrometry (MALDI-TOF-MS). Meanwhile, P. gingivalis and HSV-1 in cerebrospinal fluid (CSF) were identified by metagenome next generation sequencing (mNGS). After a quick diagnosis and a combination of antibiotics and antiviral treatment, the patient recovered and was discharged.
CONCLUSIONS: To our knowledge, this is the first report of intracranial P. gingivalis and HSV-1 infection combined with F. nucleatum bacteremia.
摘要：
背景：具核梭杆菌(F.核子）属于梭杆菌属，这是一种革兰氏阴性专性厌氧细菌。与核仁F.相关的菌血症是一种严重的并发症，这在临床上并不常见，特别是与其他颅内病原微生物感染合并时。我们首次报道了1例有核F.菌血症合并颅内牙龈卟啉单胞菌（P.牙龈）和1型单纯疱疹病毒（HSV-1）感染。
方法：一名60岁的女性因头痛入院一周，持续2天恶化。结合历史,体征和检查，以缺血性脑血管病(ICVD)为特征.通过基质辅助激光解吸/电离作用时间质谱(MALDI-TOF-MS)检测血液中的F.同时,通过宏基因组下一代测序(mNGS)鉴定脑脊液(CSF)中的牙龈卟啉单胞菌和HSV-1。在快速诊断以及抗生素和抗病毒治疗的组合后，病人康复出院。
结论：据我们所知，这是颅内牙龈卟啉单胞菌和HSV-1感染合并有核F.菌血症的首次报道。
方法：一名60岁的女性因头痛入院一周，持续2天恶化。结合历史,体征和检查，以缺血性脑血管病(ICVD)为特征.通过基质辅助激光解吸/电离作用时间质谱(MALDI-TOF-MS)检测血液中的F.同时,通过宏基因组下一代测序(mNGS)鉴定脑脊液(CSF)中的牙龈卟啉单胞菌和HSV-1。在快速诊断以及抗生素和抗病毒治疗的组合后，病人康复出院。
结论：据我们所知，这是颅内牙龈卟啉单胞菌和HSV-1感染合并有核F.菌血症的首次报道。
