Abstract：
This study compares condylar volumetric asymmetry and facial asymmetry in patients with cleft lip and/or palate (CLP) and controls. The mandibular condyle is important to facial growth, but its role in facial asymmetry for those with CLP has not been described. Condylar volumes and mandibular asymmetry were retrospectively calculated using Mimics Version 23.0 (Materialise, Leuven, Belgium) from patients with CLP undergoing computed tomography (CT) imaging and a cohort of controls. A total of 101 participants, 60 with CLP and 41 controls, had mean condylar volumetric asymmetry of 16.4 ± 17.4 % (CLP) and 6.0 ± 4.0 % (controls) (p = 0.0002). Patients with CLP who had clinically significant chin deviation (>4 mm) had more asymmetric condyles than those without significant chin deviation (p = 0.003). The chin deviated toward the smaller condyle in patients with facial asymmetry more often than in patients without facial asymmetry (81 % vs. 62 %, p = 0.033). While controls had some degree of condylar asymmetry, it tended to be milder and not associated with facial asymmetry. There is a greater degree of condylar volumetric asymmetry in patients with CLP compared to individuals in the general population. Clinically significant facial asymmetry in CLP is associated with a higher degree of condylar asymmetry, with the facial midline deviating toward the smaller condyle.
摘要：
这项研究比较了唇裂和/或腭裂（CLP）患者和对照组的con突体积不对称性和面部不对称性。下颌髁突对面部生长很重要，但是它在CLP患者面部不对称中的作用尚未被描述。使用Mimics23.0版（Materialise，鲁汶,比利时）来自接受计算机断层扫描（CT）成像的CLP患者和一组对照组。共有101人参加，60个CLP和41个控件，平均髁突体积不对称性为16.4±17.4%(CLP)和6.0±4.0%(对照)(p=0.0002)。具有临床上明显的下巴偏离（>4mm）的CLP患者比没有明显下巴偏离的患者有更多的不对称髁（p=0.003）。与没有面部不对称的患者相比，面部不对称的患者的下巴偏向较小的髁（81％与62%,p=0.033)。虽然对照组有一定程度的髁突不对称，它趋于温和，与面部不对称无关。与普通人群中的个体相比，CLP患者的髁突体积不对称程度更高。CLP中临床上显着的面部不对称与更高程度的髁不对称有关，面部中线偏向较小的髁。
