PDF(Pubmed)
Abstract：
The existing literature on the association between brain-derived neurotrophic factor (BDNF) protein levels and panic disorder presents inconsistent findings. This systematic review and meta-analysis aim to synthesize the available evidence and determine the overall effect of BDNF protein levels in individuals diagnosed with panic disorder.
A comprehensive literature search was conducted using electronic databases (PubMed, Embase, Scopus, PsycINFO, and Web of Science) from inception to April 21, 2023. The search strategy included relevant keywords and medical subject headings terms related to BDNF, panic disorder, and protein levels. A random-effects model was used for the meta-analysis, and subgroup analyses were performed to explore heterogeneity. Publication bias was assessed using funnel plots and statistical tests.
A total of 12 studies met the inclusion criteria. The meta-analysis demonstrated a significant decrease in BDNF protein levels in individuals with panic disorder (SMD = -.53, 95% CI: -1.02 to -.04, p < .001; I2 : 92%). The results of subgroup and meta-regression analyses were not statistically significant. No significant publication bias was observed based on the results of Egger\'s regression test (p-value = .3550).
This systematic review and meta-analysis provide evidence of lower BDNF protein levels in individuals diagnosed with panic disorder compared to healthy controls. The findings suggest a potential role for BDNF dysregulation in the pathophysiology of panic disorder. Further research is warranted to elucidate the underlying mechanisms and potential therapeutic implications.
A comprehensive literature search was conducted using electronic databases (PubMed, Embase, Scopus, PsycINFO, and Web of Science) from inception to April 21, 2023. The search strategy included relevant keywords and medical subject headings terms related to BDNF, panic disorder, and protein levels. A random-effects model was used for the meta-analysis, and subgroup analyses were performed to explore heterogeneity. Publication bias was assessed using funnel plots and statistical tests.
A total of 12 studies met the inclusion criteria. The meta-analysis demonstrated a significant decrease in BDNF protein levels in individuals with panic disorder (SMD = -.53, 95% CI: -1.02 to -.04, p < .001; I2 : 92%). The results of subgroup and meta-regression analyses were not statistically significant. No significant publication bias was observed based on the results of Egger\'s regression test (p-value = .3550).
This systematic review and meta-analysis provide evidence of lower BDNF protein levels in individuals diagnosed with panic disorder compared to healthy controls. The findings suggest a potential role for BDNF dysregulation in the pathophysiology of panic disorder. Further research is warranted to elucidate the underlying mechanisms and potential therapeutic implications.
摘要：
背景：关于脑源性神经营养因子（BDNF）蛋白水平与惊恐障碍之间的相关性的现有文献提出了不一致的发现。本系统评价和荟萃分析旨在综合现有证据，并确定BDNF蛋白水平在被诊断为惊恐障碍的个体中的总体作用。
方法：使用电子数据库进行了全面的文献检索(PubMed，Embase,Scopus,PsycINFO,和WebofScience)从成立到2023年4月21日。搜索策略包括与BDNF相关的相关关键词和医学主题词，恐慌症,和蛋白质水平。随机效应模型用于荟萃分析，进行亚组分析以探索异质性。使用漏斗图和统计检验评估发表偏倚。
结果：共有12项研究符合纳入标准。荟萃分析表明，恐慌症患者的BDNF蛋白水平显着降低（SMD=-.53，95％CI：-1.02至-.04，p<.001；I2：92％）。亚组和荟萃回归分析的结果无统计学意义。根据Egger回归检验结果（p值=.3550），未观察到明显的发表偏倚。
结论：本系统综述和荟萃分析提供了与健康对照组相比，诊断为惊恐障碍的个体中BDNF蛋白水平较低的证据。研究结果表明，BDNF失调在惊恐障碍的病理生理学中具有潜在作用。需要进一步的研究来阐明潜在的机制和潜在的治疗意义。
方法：使用电子数据库进行了全面的文献检索(PubMed，Embase,Scopus,PsycINFO,和WebofScience)从成立到2023年4月21日。搜索策略包括与BDNF相关的相关关键词和医学主题词，恐慌症,和蛋白质水平。随机效应模型用于荟萃分析，进行亚组分析以探索异质性。使用漏斗图和统计检验评估发表偏倚。
结果：共有12项研究符合纳入标准。荟萃分析表明，恐慌症患者的BDNF蛋白水平显着降低（SMD=-.53，95％CI：-1.02至-.04，p<.001；I2：92％）。亚组和荟萃回归分析的结果无统计学意义。根据Egger回归检验结果（p值=.3550），未观察到明显的发表偏倚。
结论：本系统综述和荟萃分析提供了与健康对照组相比，诊断为惊恐障碍的个体中BDNF蛋白水平较低的证据。研究结果表明，BDNF失调在惊恐障碍的病理生理学中具有潜在作用。需要进一步的研究来阐明潜在的机制和潜在的治疗意义。
