Abstract：
BACKGROUND: Inflammatory markers are crucial in diagnosing and monitoring rheumatoid arthritis. Patients with rheumatoid arthritis (RA) live with constant pain that limits their daily activities. Our study highlights the effects of disease activity on the quality of life in patients with rheumatoid arthritis.
METHODS: Swollen joint count (SJC), tender joint count (TJC), and visual activity scale (VAS) were utilized to acquire patients\' subjective feelings of wellness and their performance of routine daily activities to determine the disease activity. The patient\'s erythrocyte sedimentation rate (ESR) was measured at the clinical hematology laboratory using the Westergren method. The Quality of Life was rated on a scale of 1 to 10.
RESULTS: Our study found that disease activity is inversely proportional to the quality of life. Out of 111 patients, 3 (2.7%) were in remission, 1 (0.9%) had mild disease, 51 (45.9%) had moderate disease, and 56 (50.5%) had high disease activity. The ESR was normal (<20) in 11 patients (9.9%), moderately elevated (20-50) in 56 (50.5%) patients, and very high (>50) in 44 (39.6%) patients. The study revealed that 66% of patients in remission had normal, while 33% had moderately elevated ESR. 12.5% of patients with moderate disease activity had normal ESR, and none with high disease activity had normal ESR. Of 44 patients with high ESR, 7 had moderate disease activity, and 37 had high disease activity. In our study, 60% of patients had a less than 50% quality of life compared to patients with pre-arthritis.
CONCLUSIONS: High disease activity affects the productivity and quality of life in patients with rheumatoid arthritis. Assessing the impact of different interventions on the QOL should be an essential task that can help define a holistic and integrative treatment and rehabilitation model for RA patients.
METHODS: Swollen joint count (SJC), tender joint count (TJC), and visual activity scale (VAS) were utilized to acquire patients\' subjective feelings of wellness and their performance of routine daily activities to determine the disease activity. The patient\'s erythrocyte sedimentation rate (ESR) was measured at the clinical hematology laboratory using the Westergren method. The Quality of Life was rated on a scale of 1 to 10.
RESULTS: Our study found that disease activity is inversely proportional to the quality of life. Out of 111 patients, 3 (2.7%) were in remission, 1 (0.9%) had mild disease, 51 (45.9%) had moderate disease, and 56 (50.5%) had high disease activity. The ESR was normal (<20) in 11 patients (9.9%), moderately elevated (20-50) in 56 (50.5%) patients, and very high (>50) in 44 (39.6%) patients. The study revealed that 66% of patients in remission had normal, while 33% had moderately elevated ESR. 12.5% of patients with moderate disease activity had normal ESR, and none with high disease activity had normal ESR. Of 44 patients with high ESR, 7 had moderate disease activity, and 37 had high disease activity. In our study, 60% of patients had a less than 50% quality of life compared to patients with pre-arthritis.
CONCLUSIONS: High disease activity affects the productivity and quality of life in patients with rheumatoid arthritis. Assessing the impact of different interventions on the QOL should be an essential task that can help define a holistic and integrative treatment and rehabilitation model for RA patients.
摘要：
背景：炎症标志物在诊断和监测类风湿性关节炎方面至关重要。类风湿关节炎（RA）患者持续疼痛，限制了他们的日常活动。我们的研究强调了疾病活动对类风湿关节炎患者生活质量的影响。
方法：关节肿胀计数（SJC），招标接头数量（TJC），和视觉活动量表（VAS）用于获取患者的主观健康感受及其日常日常活动的表现，以确定疾病活动。在临床血液学实验室使用Westergren方法测量患者的红细胞沉降率(ESR)。生活质量以1至10的等级评定。
结果：我们的研究发现，疾病活动与生活质量成反比。111名患者中,3人（2.7％）缓解，1人（0.9%）患有轻度疾病，51人(45.9%)患有中度疾病，56（50.5%）有较高的疾病活动性。ESR正常(<20)11例(9.9%),56（50.5%）患者中度升高（20-50），和非常高（>50）44（39.6％）的患者。研究显示，66％的缓解患者正常，而33%的ESR中度升高。约12.5%的中度疾病活动度患者ESR正常,没有高疾病活动度的ESR正常。44例ESR高的患者，7有中度疾病活动，37人的疾病活动性高。在我们的研究中,与关节炎前期患者相比，60％的患者的生活质量低于50％。
结论：高疾病活动性影响类风湿关节炎患者的生产力和生活质量。评估不同干预措施对生活质量的影响应该是一项基本任务，可以帮助确定RA患者的整体和综合治疗和康复模式。
方法：关节肿胀计数（SJC），招标接头数量（TJC），和视觉活动量表（VAS）用于获取患者的主观健康感受及其日常日常活动的表现，以确定疾病活动。在临床血液学实验室使用Westergren方法测量患者的红细胞沉降率(ESR)。生活质量以1至10的等级评定。
结果：我们的研究发现，疾病活动与生活质量成反比。111名患者中,3人（2.7％）缓解，1人（0.9%）患有轻度疾病，51人(45.9%)患有中度疾病，56（50.5%）有较高的疾病活动性。ESR正常(<20)11例(9.9%),56（50.5%）患者中度升高（20-50），和非常高（>50）44（39.6％）的患者。研究显示，66％的缓解患者正常，而33%的ESR中度升高。约12.5%的中度疾病活动度患者ESR正常,没有高疾病活动度的ESR正常。44例ESR高的患者，7有中度疾病活动，37人的疾病活动性高。在我们的研究中,与关节炎前期患者相比，60％的患者的生活质量低于50％。
结论：高疾病活动性影响类风湿关节炎患者的生产力和生活质量。评估不同干预措施对生活质量的影响应该是一项基本任务，可以帮助确定RA患者的整体和综合治疗和康复模式。
