Abstract：
This narrative review aims to provide an up-to-date definition of local allergic rhinitis (LAR), its classification, mechanisms, comorbidities, recommendations for diagnosis and treatment, and define needs in this area. Both \'PubMed\' and \'Science Direct\' literature was reviewed systematically, and a manual search for studies not previously encountered in the databases was also carried out. Published studies were identified in PubMed covering the period from 1947 to 2022. The following keyword search strategy was used: (local allergic rhinitis* OR entopy* OR local Immunoglobulin E * OR nasal specific Immunoglobulin E). LAR involves Type 2 nasal inflammation with local IgE and cannot be diagnosed by systemic methods, such as skin prick or blood IgE tests. A nasal allergen challenge is necessary for diagnosis. LAR can respond to usual AR treatments, including allergen specific immunotherapy (AIT). LAR is a novel entity that requires additional investigation in terms of prevalence, proper diagnosis, treatment, and prognosis. The target outcomes and possible benefits of this review are to achieve a consensus for the study and diagnosis of LAR and increase interest in this area.
摘要：
这篇叙述性综述旨在提供局部过敏性鼻炎（LAR）的最新定义。其分类,机制,合并症,诊断和治疗的建议，并定义这方面的需求。系统回顾了“PubMed”和“ScienceDirect”文献，并对数据库中以前没有遇到的研究进行了手动搜索。在PubMed中确定了已发表的研究，涵盖了1947年至2022年的时期。使用以下关键词搜索策略:(局部变应性鼻炎*ORentopt*OR局部免疫球蛋白E*OR鼻特异性免疫球蛋白E)。LAR涉及2型鼻腔炎症和局部IgE，不能通过全身方法诊断。如皮肤点刺或血液IgE测试。鼻过敏原攻击对于诊断是必要的。LAR可以对通常的AR治疗有反应，包括过敏原特异性免疫疗法（AIT）。LAR是一种新颖的实体，需要对患病率进行额外的调查，正确的诊断,治疗,和预后。本综述的目标结果和可能的益处是为LAR的研究和诊断达成共识，并增加对该领域的兴趣。
