PDF(Pubmed)
Abstract：
UNASSIGNED: Use of injectable-platelet rich fibrin (i-PRF) in the field of periodontal regeneration is quite well known due to its efficacy. The study was aimed to evaluate the platelet derived growth factor-BB (PDGF-BB) levels in cases of isolated gingival recession using gingival pedicle split thickness tunnel technique (GPST) and de-epithelialized gingival graft (DGG) with or without coating it with i-PRF.
UNASSIGNED: 20 patients exhibiting Miller\'s class I/II isolated gingival recession were selected for this parallel arm randomized controlled trial. Recipient site was prepared using GPST technique, free gingival graft was harvested and de-epithelialized, further graft was coated with i-PRF and wound fluid samples from surgical site were collected at baseline, 3rd day and 7th day for group A. The same procedure without coating the graft in i-PRF was carried out for group B. Clinical parameters like probing depth, recession depth, recession width, width of keratinized gingiva, wound healing index (WHI), complete root coverage was recorded at baseline and after 4 months.
UNASSIGNED: Significant intergroup difference was seen in WHI and the levels of PDGF-BB from baseline to the last estimated time point (p < 0.05).
UNASSIGNED: The study emphasizes on the use of novel GPST technique in conjunction with DGG coated with liquid PRF, which has shown sustained release of PDGF-BB resulting in better wound healing.
UNASSIGNED: 20 patients exhibiting Miller\'s class I/II isolated gingival recession were selected for this parallel arm randomized controlled trial. Recipient site was prepared using GPST technique, free gingival graft was harvested and de-epithelialized, further graft was coated with i-PRF and wound fluid samples from surgical site were collected at baseline, 3rd day and 7th day for group A. The same procedure without coating the graft in i-PRF was carried out for group B. Clinical parameters like probing depth, recession depth, recession width, width of keratinized gingiva, wound healing index (WHI), complete root coverage was recorded at baseline and after 4 months.
UNASSIGNED: Significant intergroup difference was seen in WHI and the levels of PDGF-BB from baseline to the last estimated time point (p < 0.05).
UNASSIGNED: The study emphasizes on the use of novel GPST technique in conjunction with DGG coated with liquid PRF, which has shown sustained release of PDGF-BB resulting in better wound healing.
摘要：
■在牙周再生领域中使用可注射的富血小板纤维蛋白(i-PRF)由于其功效而众所周知。该研究旨在使用牙龈蒂分裂厚度隧道技术（GPST）和去上皮化牙龈移植物（DGG）评估孤立性牙龈退缩的情况下的血小板衍生生长因子-BB（PDGF-BB）水平用i-PRF包被。
■选择了20名表现出Miller的I/II级孤立性牙龈退缩的患者进行这项平行臂随机对照试验。收件人网站使用GPST技术制备，收获游离的牙龈移植物并去上皮，进一步的移植物用i-PRF包被，并在基线时收集手术部位的伤口液样本，A组的第3天和第7天，B组进行了相同的程序，没有在i-PRF中涂覆移植物。临床参数，如探测深度，衰退深度，衰退宽度，角化牙龈的宽度，伤口愈合指数（WHI），在基线和4个月后记录完整的根系覆盖率.
■从基线到最后估计的时间点，在WHI和PDGF-BB水平方面观察到明显的组间差异（p<0.05）。
■该研究强调将新型GPST技术与涂有液体PRF的DGG结合使用，这表明PDGF-BB的持续释放导致更好的伤口愈合。
■选择了20名表现出Miller的I/II级孤立性牙龈退缩的患者进行这项平行臂随机对照试验。收件人网站使用GPST技术制备，收获游离的牙龈移植物并去上皮，进一步的移植物用i-PRF包被，并在基线时收集手术部位的伤口液样本，A组的第3天和第7天，B组进行了相同的程序，没有在i-PRF中涂覆移植物。临床参数，如探测深度，衰退深度，衰退宽度，角化牙龈的宽度，伤口愈合指数（WHI），在基线和4个月后记录完整的根系覆盖率.
■从基线到最后估计的时间点，在WHI和PDGF-BB水平方面观察到明显的组间差异（p<0.05）。
■该研究强调将新型GPST技术与涂有液体PRF的DGG结合使用，这表明PDGF-BB的持续释放导致更好的伤口愈合。
