PDF(Pubmed)
Abstract：
UNASSIGNED: Patients with end stage renal disease (ESRD) are at a higher risk of developing tuberculosis (TB) due to the immunosuppressed state along with concomitant comorbidities and socioeconomic and demographic factors. Data on the prevalence of tuberculosis in ESRD are scarce despite the high burden of the disease in developing nations.
UNASSIGNED: A multicenter, cross-sectional study was conducted at eight dialysis centers in Addis Ababa on the prevalence of TB among CKD patients on maintenance hemodialysis from August 2022 to October 2022 G.C. The study enrolled 263 participants selected by systematic random sampling. Data were collected by reviewing the patient\'s electronic medical records. The Collected data were analyzed using SPSS version 26.0.
UNASSIGNED: Our study found a 27% prevalence of TB in patients with ESRD receiving maintenance hemodialysis (MHD). Pulmonary tuberculosis was the most prevalent form, and lymphadenitis was the most common extra-pulmonary tuberculosis (EPTB). Only 5.6% of the study participants had microbiologic evidence of TB. Chemistry and cytological studies from pleural fluid and imaging evidences were commonly used diagnostic modalities. The presence of HIV infection, longer duration of dialysis (>1 year), and contact history with a known TB patient were all significantly associated with higher prevalence of TB among the study participants.
UNASSIGNED: Although there is a strong association between TB and CKD, there are no local data from Ethiopia. Our study identified a higher prevalence of TB among CKD patients on MHD. Thus, maintaining a high index of suspicion and early diagnosis and treatment of TB among ESRD patients on MHD and use of TB preventive therapy (TPT) is important in decreasing morbidity and mortality.
UNASSIGNED: A multicenter, cross-sectional study was conducted at eight dialysis centers in Addis Ababa on the prevalence of TB among CKD patients on maintenance hemodialysis from August 2022 to October 2022 G.C. The study enrolled 263 participants selected by systematic random sampling. Data were collected by reviewing the patient\'s electronic medical records. The Collected data were analyzed using SPSS version 26.0.
UNASSIGNED: Our study found a 27% prevalence of TB in patients with ESRD receiving maintenance hemodialysis (MHD). Pulmonary tuberculosis was the most prevalent form, and lymphadenitis was the most common extra-pulmonary tuberculosis (EPTB). Only 5.6% of the study participants had microbiologic evidence of TB. Chemistry and cytological studies from pleural fluid and imaging evidences were commonly used diagnostic modalities. The presence of HIV infection, longer duration of dialysis (>1 year), and contact history with a known TB patient were all significantly associated with higher prevalence of TB among the study participants.
UNASSIGNED: Although there is a strong association between TB and CKD, there are no local data from Ethiopia. Our study identified a higher prevalence of TB among CKD patients on MHD. Thus, maintaining a high index of suspicion and early diagnosis and treatment of TB among ESRD patients on MHD and use of TB preventive therapy (TPT) is important in decreasing morbidity and mortality.
摘要：
患有终末期肾病(ESRD)的患者由于免疫抑制状态以及伴随的合并症和社会经济和人口统计学因素而处于发展为结核病(TB)的较高风险。尽管发展中国家的结核病负担很高，但有关ESRD结核病患病率的数据却很少。
■一个多中心，本研究于2022年8月至2022年10月在亚的斯亚贝巴的8个透析中心进行了一项横断面研究,研究了CKD维持性血液透析患者中TB的患病率。本研究纳入了通过系统随机抽样选择的263名参与者.通过查看患者的电子病历收集数据。使用SPSS版本26.0分析收集的数据。
■我们的研究发现，在接受维持性血液透析（MHD）的ESRD患者中，结核病的患病率为27％。肺结核是最常见的形式，淋巴结炎是最常见的肺外结核（EPTB）。只有5.6%的研究参与者有结核病的微生物学证据。胸膜液的化学和细胞学研究以及影像学证据是常用的诊断方式。艾滋病毒感染的存在，透析时间较长（>1年），与已知TB患者的接触史均与研究参与者中TB患病率较高显著相关.
■尽管TB和CKD之间有很强的关联，埃塞俄比亚没有当地数据。我们的研究发现，MHD患者中结核病的患病率较高。因此，在接受MHD治疗的ESRD患者中,保持高的怀疑指数和结核病的早期诊断和治疗,以及使用结核病预防性治疗(TPT)对降低发病率和死亡率很重要.
■一个多中心，本研究于2022年8月至2022年10月在亚的斯亚贝巴的8个透析中心进行了一项横断面研究,研究了CKD维持性血液透析患者中TB的患病率。本研究纳入了通过系统随机抽样选择的263名参与者.通过查看患者的电子病历收集数据。使用SPSS版本26.0分析收集的数据。
■我们的研究发现，在接受维持性血液透析（MHD）的ESRD患者中，结核病的患病率为27％。肺结核是最常见的形式，淋巴结炎是最常见的肺外结核（EPTB）。只有5.6%的研究参与者有结核病的微生物学证据。胸膜液的化学和细胞学研究以及影像学证据是常用的诊断方式。艾滋病毒感染的存在，透析时间较长（>1年），与已知TB患者的接触史均与研究参与者中TB患病率较高显著相关.
■尽管TB和CKD之间有很强的关联，埃塞俄比亚没有当地数据。我们的研究发现，MHD患者中结核病的患病率较高。因此，在接受MHD治疗的ESRD患者中,保持高的怀疑指数和结核病的早期诊断和治疗,以及使用结核病预防性治疗(TPT)对降低发病率和死亡率很重要.
