PDF(Pubmed)
Abstract：
UNASSIGNED: Carotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. The miRNA-29c was reported to promote the phenotype transformation of vascular smooth muscle cells (VSMCs) in diabetes mice, eventually leading to plaque formation and bleeding. However, such studies are rare and limited to animal experiments.
UNASSIGNED: In our study, 40 patients were divided into a diabetic mellitus (DM) group and a non-DM group according to whether they were diagnosed with DM. Then, the real-time quantitative PCR was applied to examine the miRNA-29c level in human carotid plaque tissue derived from 40 subjects receiving carotid endarterectomy.
UNASSIGNED: Briefly, diabetes patients had a decreased miRNA-29c level as compared with non-DM subjects, and this comparison was statistically significant (P = 0.02). Notably, variable miRNA-29c level was negatively associated with HbA1c level, although no statistical significance was observed. Moreover, there was an increased miRNA-29c level in patients with cerebral stroke.
UNASSIGNED: Collectively, the miRNA-29c level in the carotid plaque is closely associated with DM and cerebral stroke, which may contribute to atherosclerosis formation.
UNASSIGNED: In our study, 40 patients were divided into a diabetic mellitus (DM) group and a non-DM group according to whether they were diagnosed with DM. Then, the real-time quantitative PCR was applied to examine the miRNA-29c level in human carotid plaque tissue derived from 40 subjects receiving carotid endarterectomy.
UNASSIGNED: Briefly, diabetes patients had a decreased miRNA-29c level as compared with non-DM subjects, and this comparison was statistically significant (P = 0.02). Notably, variable miRNA-29c level was negatively associated with HbA1c level, although no statistical significance was observed. Moreover, there was an increased miRNA-29c level in patients with cerebral stroke.
UNASSIGNED: Collectively, the miRNA-29c level in the carotid plaque is closely associated with DM and cerebral stroke, which may contribute to atherosclerosis formation.
摘要：
■颈动脉粥样硬化是缺血性卒中的主要原因,缺血性中风是全球发病率和死亡率的主要原因。不幸的是,动脉粥样硬化斑块形成的原因尚不清楚.miRNA-29c可促进糖尿病小鼠血管平滑肌细胞(VSMCs)的表型转化,最终导致斑块形成和出血。然而,这种研究很少见，仅限于动物实验。
■在我们的研究中，根据是否诊断为DM，将40例患者分为糖尿病（DM）组和非DM组。然后，应用实时定量PCR检测来自40例接受颈动脉内膜切除术的受试者的人颈动脉斑块组织中的miRNA-29c水平.
■简而言之，与非DM受试者相比，糖尿病患者的miRNA-29c水平降低，这种比较具有统计学意义(P=0.02)。值得注意的是,可变miRNA-29c水平与HbA1c水平呈负相关，尽管没有观察到统计学意义。此外，卒中患者的miRNA-29c水平升高.
■集体，颈动脉斑块中miRNA-29c水平与DM和脑卒中密切相关,这可能有助于动脉粥样硬化的形成。
■在我们的研究中，根据是否诊断为DM，将40例患者分为糖尿病（DM）组和非DM组。然后，应用实时定量PCR检测来自40例接受颈动脉内膜切除术的受试者的人颈动脉斑块组织中的miRNA-29c水平.
■简而言之，与非DM受试者相比，糖尿病患者的miRNA-29c水平降低，这种比较具有统计学意义(P=0.02)。值得注意的是,可变miRNA-29c水平与HbA1c水平呈负相关，尽管没有观察到统计学意义。此外，卒中患者的miRNA-29c水平升高.
■集体，颈动脉斑块中miRNA-29c水平与DM和脑卒中密切相关,这可能有助于动脉粥样硬化的形成。
