UNASSIGNED: In our study, 40 patients were divided into a diabetic mellitus (DM) group and a non-DM group according to whether they were diagnosed with DM. Then, the real-time quantitative PCR was applied to examine the miRNA-29c level in human carotid plaque tissue derived from 40 subjects receiving carotid endarterectomy.
UNASSIGNED: Briefly, diabetes patients had a decreased miRNA-29c level as compared with non-DM subjects, and this comparison was statistically significant (P = 0.02). Notably, variable miRNA-29c level was negatively associated with HbA1c level, although no statistical significance was observed. Moreover, there was an increased miRNA-29c level in patients with cerebral stroke.
UNASSIGNED: Collectively, the miRNA-29c level in the carotid plaque is closely associated with DM and cerebral stroke, which may contribute to atherosclerosis formation.
■在我们的研究中,根据是否诊断为DM,将40例患者分为糖尿病(DM)组和非DM组。然后,应用实时定量PCR检测来自40例接受颈动脉内膜切除术的受试者的人颈动脉斑块组织中的miRNA-29c水平.
■简而言之,与非DM受试者相比,糖尿病患者的miRNA-29c水平降低,这种比较具有统计学意义(P=0.02)。值得注意的是,可变miRNA-29c水平与HbA1c水平呈负相关,尽管没有观察到统计学意义。此外,卒中患者的miRNA-29c水平升高.
■集体,颈动脉斑块中miRNA-29c水平与DM和脑卒中密切相关,这可能有助于动脉粥样硬化的形成。