UNASSIGNED: We retrospectively analyzed the records of 796 patients who underwent curative surgical resection for pathologic stage IA/IB NSCLC (i.e., visceral pleural invasion only) at a single center from 2008 to 2017. Patients were classified based on tumor abutment and then reclassified by the presence of visceral pleural invasion. Clinical characteristics, pathological features, and survival rates were compared.
UNASSIGNED: The study included 181 patients with abutting NSCLC (22.7% of all participants) and 615 with non-abutting tumors (77.3%). Those with tumor abutment exhibited higher rates of non-adenocarcinoma (26.5% vs. 9.9%, p<0.01) and visceral/lymphatic/vascular invasion (30.4%/33.1%/12.7% vs. 8.5%/22.4%/5.7%, respectively; p<0.01) compared to those without abutment. Multivariable analysis identified lymphatic invasion and male sex as risk factors for overall survival (OS) and disease-free survival (DFS) in stage I NSCLC measuring 3 cm or smaller. Age, smoking history, vascular invasion, and recurrence emerged as risk factors for OS, whereas the presence of non-pure ground-glass opacity was a risk factor for DFS.
UNASSIGNED: NSCLC lesions 3 cm or smaller that abut adjacent structures present higher rates of various risk factors than non-abutting lesions, necessitating evaluation of tumor invasion into adjacent structures and lymph node metastasis. In isolation, however, the presence of tumor abutment without visceral pleural invasion does not constitute a risk factor.
■我们回顾性分析了796例因IA/IB期非小细胞肺癌接受根治性手术切除的患者的记录(即,仅内脏胸膜侵犯)从2008年到2017年在单个中心。根据肿瘤基台对患者进行分类,然后根据内脏胸膜侵犯的情况对患者进行重新分类。临床特征,病理特征,并对生存率进行了比较。
■该研究包括181例邻接NSCLC患者(占所有参与者的22.7%)和615例非邻接肿瘤患者(77.3%)。有肿瘤基牙的非腺癌发生率较高(26.5%vs.9.9%,p<0.01)和内脏/淋巴/血管浸润(30.4%/33.1%/12.7%vs.8.5%/22.4%/5.7%,分别;p<0.01)与没有基台的相比。多变量分析确定淋巴管浸润和男性是3厘米或更小的I期NSCLC总生存期(OS)和无病生存期(DFS)的危险因素。年龄,吸烟史,血管浸润,复发成为OS的危险因素,而非纯毛玻璃不透明的存在是DFS的危险因素。
■与邻近结构邻接的3厘米或更小的非小细胞肺癌病变比非邻接病变的各种危险因素发生率更高,需要评估肿瘤对邻近结构的侵袭和淋巴结转移。孤立地,然而,没有内脏胸膜侵犯的肿瘤基台的存在并不构成危险因素。