PDF(Pubmed)
Abstract：
Colorectal cancer (CRC) stands as one of the most prevalent form of cancer globally, causing a significant number of deaths, surpassing 0.9 million in the year 2020. According to GLOBOCAN 2020, CRC ranks third in incidence and second in mortality in both males and females. Despite extensive studies over the years, there is still a need to establish novel therapeutic targets to enhance the patients\' survival rate in CRC. Nuclear receptors (NRs) are ligand-activated transcription factors (TFs) that regulate numerous essential biological processes such as differentiation, development, physiology, reproduction, and cellular metabolism. Dysregulation and anomalous expression of different NRs has led to multiple alterations, such as impaired signaling cascades, mutations, and epigenetic changes, leading to various diseases, including cancer. It has been observed that differential expression of various NRs might lead to the initiation and progression of CRC, and are correlated with poor survival outcomes in CRC patients. Despite numerous studies on the mechanism and role of NRs in this cancer, it remains of significant scientific interest primarily due to the diverse functions that various NRs exhibit in regulating key hallmarks of this cancer. Thus, modulating the expression of NRs with their agonists and antagonists, based on their expression levels, holds an immense prospect in the diagnosis, prognosis, and therapeutical modalities of CRC. In this review, we primarily focus on the role and mechanism of NRs in the pathogenesis of CRC and emphasized the significance of targeting these NRs using a variety of agents, which may represent a novel and effective strategy for the prevention and treatment of this cancer.
摘要：
结直肠癌（CRC）是全球最普遍的癌症之一。导致大量死亡，2020年超过90万。根据GLOBOCAN2020，在男性和女性中，CRC的发病率排名第三，死亡率排名第二。尽管多年来进行了广泛的研究，仍需要建立新的治疗靶点来提高CRC患者的生存率.核受体（NRs）是配体激活的转录因子（TF），可调节许多重要的生物学过程，如分化，发展,生理学,繁殖，和细胞代谢。不同NRs的失调和异常表达导致了多种改变，例如受损的信号级联，突变,和表观遗传变化，导致各种疾病，包括癌症.已经观察到各种NRs的差异表达可能导致CRC的开始和进展。并且与CRC患者的不良生存结局相关。尽管对NRs在这种癌症中的机制和作用进行了大量研究，它仍然具有重要的科学兴趣，主要是由于各种NRs在调节这种癌症的关键标志方面表现出的不同功能。因此，用它们的激动剂和拮抗剂调节NRs的表达，根据他们的表达水平，在诊断中拥有巨大的前景，预后,和CRC的治疗方式。在这次审查中,我们主要关注NRs在CRC发病机制中的作用和机制，并强调使用多种药物靶向这些NRs的重要性，这可能是预防和治疗这种癌症的一种新颖有效的策略。
