Abstract：
BACKGROUND: Pediatric inflammatory bowel disease (pIBD) incidence has increased over the last 25 years. We aim to report contemporaneous trends across the South West United Kingdom.
METHODS: Data were provided from centers covering the South West United Kingdom (Bristol, Oxford, Cardiff, Exeter, and Southampton), with a total area at-risk population (<18 years of age) of 2 947 534. Cases were retrieved from 2013 to 2022. Incident rates were reported per 100 000 at-risk population, with temporal trends analyzed through correlation. Subgroup analysis was undertaken for age groups (0-6, 6-11, and 12-17 years of age), sex, and disease subtype. Choropleth maps were created for local districts.
RESULTS: In total, 2497 pIBD cases were diagnosed between 2013 and 2022, with a mean age of 12.6 years (38.7% female). Diagnosis numbers increased from 187 to 376, with corresponding incidence rates of 6.0 per 100 000 population per year (2013) to 12.4 per 100 000 population per year (2022) (b = 0.918, P < .01). Female rates increased from 5.1 per 100 000 population per year in 2013 to 11.0 per 100 000 population per year in 2022 (b = 0.865, P = .01). Male rates increased from 5.7 per 100 000 population per year to 14.4 per 100 000 population per year (b = 0.832, P = .03). Crohn\'s disease incidence increased from 3.1 per 100 000 population per year to 6.3 per 100 000 population per year (b = 0.897, P < .01). Ulcerative colitis increased from 2.3 per 100 000 population per year to 4.3 per 100 000 population per year (b = 0.813, P = .04). Inflammatory bowel disease unclassified also increased, from 0.6 per 100 000 population per year to 1.8 per 100 000 population per year (b = 0.851, P = .02). Statistically significant increases were seen in those ≥12 to 17 years of age, from 11.2 per 100 000 population per year to 24.6 per 100 000 population per year (b = 0.912, P < .01), and the 7- to 11-year-old age group, with incidence rising from 4.4 per 100 000 population per year to 7.6 per 100 000 population per year (b = 0.878, P = .01). There was no statistically significant increase in very early onset inflammatory bowel disease (≤6 years of age) (b = 0.417, P = .231).
CONCLUSIONS: We demonstrate significant increases in pIBD incidence across a large geographical area including multiple referral centers. Increasing incidence has implications for service provision for services managing pIBD.
Incidence of inflammatory bowel disease continues to increase in childhood, particularly in older children. This is demonstrated in a contemporary dataset collected over a 10-year period, and covering an at-risk population of nearly 3 000 000. These data have significant implications for service provision.
METHODS: Data were provided from centers covering the South West United Kingdom (Bristol, Oxford, Cardiff, Exeter, and Southampton), with a total area at-risk population (<18 years of age) of 2 947 534. Cases were retrieved from 2013 to 2022. Incident rates were reported per 100 000 at-risk population, with temporal trends analyzed through correlation. Subgroup analysis was undertaken for age groups (0-6, 6-11, and 12-17 years of age), sex, and disease subtype. Choropleth maps were created for local districts.
RESULTS: In total, 2497 pIBD cases were diagnosed between 2013 and 2022, with a mean age of 12.6 years (38.7% female). Diagnosis numbers increased from 187 to 376, with corresponding incidence rates of 6.0 per 100 000 population per year (2013) to 12.4 per 100 000 population per year (2022) (b = 0.918, P < .01). Female rates increased from 5.1 per 100 000 population per year in 2013 to 11.0 per 100 000 population per year in 2022 (b = 0.865, P = .01). Male rates increased from 5.7 per 100 000 population per year to 14.4 per 100 000 population per year (b = 0.832, P = .03). Crohn\'s disease incidence increased from 3.1 per 100 000 population per year to 6.3 per 100 000 population per year (b = 0.897, P < .01). Ulcerative colitis increased from 2.3 per 100 000 population per year to 4.3 per 100 000 population per year (b = 0.813, P = .04). Inflammatory bowel disease unclassified also increased, from 0.6 per 100 000 population per year to 1.8 per 100 000 population per year (b = 0.851, P = .02). Statistically significant increases were seen in those ≥12 to 17 years of age, from 11.2 per 100 000 population per year to 24.6 per 100 000 population per year (b = 0.912, P < .01), and the 7- to 11-year-old age group, with incidence rising from 4.4 per 100 000 population per year to 7.6 per 100 000 population per year (b = 0.878, P = .01). There was no statistically significant increase in very early onset inflammatory bowel disease (≤6 years of age) (b = 0.417, P = .231).
CONCLUSIONS: We demonstrate significant increases in pIBD incidence across a large geographical area including multiple referral centers. Increasing incidence has implications for service provision for services managing pIBD.
Incidence of inflammatory bowel disease continues to increase in childhood, particularly in older children. This is demonstrated in a contemporary dataset collected over a 10-year period, and covering an at-risk population of nearly 3 000 000. These data have significant implications for service provision.
摘要：
背景：在过去的25年中，小儿炎症性肠病（pIBD）的发病率有所增加。我们的目标是报告整个英国西南部的同期趋势。
方法：数据来自英国西南部的中心（布里斯托尔，牛津,卡迪夫,埃克塞特,和南安普敦)，高危人群（<18岁）的总面积为2947534。从2013年到2022年检索了病例。报告的事件发生率为每10万风险人群，通过相关性分析时间趋势。对年龄组（0-6、6-11和12-17岁）进行亚组分析，性别,和疾病亚型。Choropleth地图是为当地地区创建的。
结果：总计，在2013年至2022年之间诊断出2497例pIBD病例，平均年龄为12.6岁（38.7％为女性）。诊断人数从187增加到376，相应的发病率为每年每10万人口6.0（2013年）到每年每10万人口12.4（2022年）（b=0.918，P<0.01）。女性比率从2013年的每年每10万人口5.1人增加到2022年的每年每10万人口11.0人（b=0.865，P=0.01）。男性比率从每年每10万人口5.7增加到每年每10万人口14.4（b=0.832，P=0.03）。克罗恩病发病率从每年3.1/10万人口增加到每年6.3/10万人口(b=0.897,P<.01)。溃疡性结肠炎从每年每10万人口2.3增加到每年每10万人口4.3（b=0.813，P=.04）。未分类的炎症性肠病也有所增加，从每年每10万人口0.6到每年每10万人口1.8（b=0.851，P=.02）。在≥12至17岁的人群中观察到统计学上的显着增加，从每年每10万人口11.2到每年每10万人口24.6(b=0.912，P<0.01)，以及7至11岁的年龄组，发病率从每年每100000人口4.4上升到每年每100000人口7.6（b=0.878，P=0.01）。非常早发性炎症性肠病（≤6岁）没有统计学上的显着增加（b=0.417，P=0.231）。
结论：我们证明，在包括多个转诊中心在内的广大地理区域，pIBD发病率显著增加。发病率的增加对管理pIBD的服务提供有影响。
儿童时期炎症性肠病的发病率持续增加，尤其是年龄较大的儿童。这在10年期间收集的当代数据集中得到了证明，并覆盖了近3000000的高危人群。这些数据对服务提供具有重要意义。
方法：数据来自英国西南部的中心（布里斯托尔，牛津,卡迪夫,埃克塞特,和南安普敦)，高危人群（<18岁）的总面积为2947534。从2013年到2022年检索了病例。报告的事件发生率为每10万风险人群，通过相关性分析时间趋势。对年龄组（0-6、6-11和12-17岁）进行亚组分析，性别,和疾病亚型。Choropleth地图是为当地地区创建的。
结果：总计，在2013年至2022年之间诊断出2497例pIBD病例，平均年龄为12.6岁（38.7％为女性）。诊断人数从187增加到376，相应的发病率为每年每10万人口6.0（2013年）到每年每10万人口12.4（2022年）（b=0.918，P<0.01）。女性比率从2013年的每年每10万人口5.1人增加到2022年的每年每10万人口11.0人（b=0.865，P=0.01）。男性比率从每年每10万人口5.7增加到每年每10万人口14.4（b=0.832，P=0.03）。克罗恩病发病率从每年3.1/10万人口增加到每年6.3/10万人口(b=0.897,P<.01)。溃疡性结肠炎从每年每10万人口2.3增加到每年每10万人口4.3（b=0.813，P=.04）。未分类的炎症性肠病也有所增加，从每年每10万人口0.6到每年每10万人口1.8（b=0.851，P=.02）。在≥12至17岁的人群中观察到统计学上的显着增加，从每年每10万人口11.2到每年每10万人口24.6(b=0.912，P<0.01)，以及7至11岁的年龄组，发病率从每年每100000人口4.4上升到每年每100000人口7.6（b=0.878，P=0.01）。非常早发性炎症性肠病（≤6岁）没有统计学上的显着增加（b=0.417，P=0.231）。
结论：我们证明，在包括多个转诊中心在内的广大地理区域，pIBD发病率显著增加。发病率的增加对管理pIBD的服务提供有影响。
儿童时期炎症性肠病的发病率持续增加，尤其是年龄较大的儿童。这在10年期间收集的当代数据集中得到了证明，并覆盖了近3000000的高危人群。这些数据对服务提供具有重要意义。
