PDF(Pubmed)
Abstract：
UNASSIGNED: Cognitive function has an important role in determining the quality of life of older adults. Cardiovascular disease (CVD) is common in older people and may compromise cognitive performance; however, the extent to which this is related to carotid atherosclerosis is unclear.
UNASSIGNED: We investigated associations between carotid atherosclerosis and cognitive function and neuroimaging markers of brain health in a UK multi-ethnic community-based sample including older people of European, South Asian, and African-Caribbean ethnicity.
UNASSIGNED: Carotid plaques and intima-media thickness (cIMT) were assessed using ultrasound in 985 people (mean age 73.2y, 56 % male). Associations of carotid atherosclerosis with cognitive function (memory, executive function, language and CSI-D, a global measure of cognitive state) and neuroimaging measures (total brain volume, hippocampal volume, white matter (WM) lesion volume and coalescence score) were analysed using regression analyses, with and without adjustment for potential confounders using two models: 1) adjustment for age, sex, and ethnicity; 2) model 1 plus education, physical activity category, body mass index, hypertension, diabetes, total and high density lipoprotein cholesterol, atrial fibrillation, smoking, previous CVD, alcohol consumption, and presence of chronic kidney disease.
UNASSIGNED: People with carotid plaque or higher cIMT had lower CSI-D score, poorer memory poorer executive function and higher WM lesion volume and coalescence. Language was poorer in people with plaque but was not correlated with cIMT. Associations with plaque were preserved after full adjustment (model 2) but relationships for cIMT were attenuated. Associations with other plaque characteristics were generally unconvincing after adjustment.
UNASSIGNED: This multi-ethnic cohort study provides evidence that presence of carotid plaque, is associated with poorer cognitive function and brain health.
UNASSIGNED: We investigated associations between carotid atherosclerosis and cognitive function and neuroimaging markers of brain health in a UK multi-ethnic community-based sample including older people of European, South Asian, and African-Caribbean ethnicity.
UNASSIGNED: Carotid plaques and intima-media thickness (cIMT) were assessed using ultrasound in 985 people (mean age 73.2y, 56 % male). Associations of carotid atherosclerosis with cognitive function (memory, executive function, language and CSI-D, a global measure of cognitive state) and neuroimaging measures (total brain volume, hippocampal volume, white matter (WM) lesion volume and coalescence score) were analysed using regression analyses, with and without adjustment for potential confounders using two models: 1) adjustment for age, sex, and ethnicity; 2) model 1 plus education, physical activity category, body mass index, hypertension, diabetes, total and high density lipoprotein cholesterol, atrial fibrillation, smoking, previous CVD, alcohol consumption, and presence of chronic kidney disease.
UNASSIGNED: People with carotid plaque or higher cIMT had lower CSI-D score, poorer memory poorer executive function and higher WM lesion volume and coalescence. Language was poorer in people with plaque but was not correlated with cIMT. Associations with plaque were preserved after full adjustment (model 2) but relationships for cIMT were attenuated. Associations with other plaque characteristics were generally unconvincing after adjustment.
UNASSIGNED: This multi-ethnic cohort study provides evidence that presence of carotid plaque, is associated with poorer cognitive function and brain health.
摘要：
■认知功能在决定老年人的生活质量方面具有重要作用。心血管疾病（CVD）在老年人中很常见，可能会损害认知能力；然而，这与颈动脉粥样硬化相关的程度尚不清楚.
■我们在英国多种族社区样本中调查了颈动脉粥样硬化与认知功能和脑健康的神经影像学指标之间的关联，包括欧洲老年人，南亚,和非洲-加勒比种族。
■使用超声评估了985人的颈动脉斑块和内膜中层厚度（cIMT）（平均年龄73.2岁，56%男性）。颈动脉粥样硬化与认知功能的关系(记忆，执行功能，语言和CSI-D，认知状态的全局测量)和神经影像学测量(大脑总体积，海马体积,白质（WM）病变体积和合并评分）使用回归分析进行分析，使用两个模型对潜在混杂因素进行调整和不进行调整：1)对年龄进行调整，性别,和种族；2)模式1加教育，身体活动类别,身体质量指数,高血压,糖尿病,总和高密度脂蛋白胆固醇，心房颤动,吸烟,以前的CVD，酒精消费,和慢性肾病的存在。
■颈动脉斑块或cIMT较高的人CSI-D评分较低，记忆较差，执行功能较差，WM病变体积和合并较高。有斑块的人语言较差，但与cIMT无关。完全调整后保留了与斑块的关联（模型2），但cIMT的关系减弱。调整后，与其他斑块特征的关联通常无法令人信服。
■这项多种族队列研究提供了证据，证明颈动脉斑块的存在，与较差的认知功能和大脑健康有关。
■我们在英国多种族社区样本中调查了颈动脉粥样硬化与认知功能和脑健康的神经影像学指标之间的关联，包括欧洲老年人，南亚,和非洲-加勒比种族。
■使用超声评估了985人的颈动脉斑块和内膜中层厚度（cIMT）（平均年龄73.2岁，56%男性）。颈动脉粥样硬化与认知功能的关系(记忆，执行功能，语言和CSI-D，认知状态的全局测量)和神经影像学测量(大脑总体积，海马体积,白质（WM）病变体积和合并评分）使用回归分析进行分析，使用两个模型对潜在混杂因素进行调整和不进行调整：1)对年龄进行调整，性别,和种族；2)模式1加教育，身体活动类别,身体质量指数,高血压,糖尿病,总和高密度脂蛋白胆固醇，心房颤动,吸烟,以前的CVD，酒精消费,和慢性肾病的存在。
■颈动脉斑块或cIMT较高的人CSI-D评分较低，记忆较差，执行功能较差，WM病变体积和合并较高。有斑块的人语言较差，但与cIMT无关。完全调整后保留了与斑块的关联（模型2），但cIMT的关系减弱。调整后，与其他斑块特征的关联通常无法令人信服。
■这项多种族队列研究提供了证据，证明颈动脉斑块的存在，与较差的认知功能和大脑健康有关。
