PDF(Pubmed)
Abstract：
UNASSIGNED: Kimura disease (KD) presents a diagnostic challenge to clinicians because of its rarity and atypical symptoms in its early stages, and it is difficult to treat and prone to recurrence or involvement of other organs.
UNASSIGNED: This study aims to investigate the possible relevance of renal involvement and recurrence by analysing the clinical presentations, laboratory results, histopathological features, therapeutic data and follow-up results of KD.
UNASSIGNED: A total of 27 patients diagnosed as KD in two hospitals from January 1999 to December 2021 were analysed retrospectively in this study based on the diagnosis of histopathology.
UNASSIGNED: KD mainly affected male more than female (8:1) with the onset age ranging from 3 to 58 years (median 29.8 years). The common initial symptoms included subcutaneous soft tissue or lymph node enlargement, non-specific skin lesions and proteinuria. One patient presented cough and expectoration as the first symptoms. KD patients often had high levels of serum immunoglobulin E (IgE) and basophils, which exhibited a significantly positive correlation with renal involvement and recurrence (p < 0.05). Early mass resection could prevent the development of nephritis and decrease the risk of relapse (p < 0.05).
UNASSIGNED: KD should be noted in patients presenting with intractable and relapsing atopic skin lesions and (or) subcutaneous mass. Patients with high levels of serum IgE and blood basophils may be prone to developing KD-associated nephritis and predict a high risk of recurrence. Early surgical removal of the mass may result in a better prognosis.
UNASSIGNED: This study aims to investigate the possible relevance of renal involvement and recurrence by analysing the clinical presentations, laboratory results, histopathological features, therapeutic data and follow-up results of KD.
UNASSIGNED: A total of 27 patients diagnosed as KD in two hospitals from January 1999 to December 2021 were analysed retrospectively in this study based on the diagnosis of histopathology.
UNASSIGNED: KD mainly affected male more than female (8:1) with the onset age ranging from 3 to 58 years (median 29.8 years). The common initial symptoms included subcutaneous soft tissue or lymph node enlargement, non-specific skin lesions and proteinuria. One patient presented cough and expectoration as the first symptoms. KD patients often had high levels of serum immunoglobulin E (IgE) and basophils, which exhibited a significantly positive correlation with renal involvement and recurrence (p < 0.05). Early mass resection could prevent the development of nephritis and decrease the risk of relapse (p < 0.05).
UNASSIGNED: KD should be noted in patients presenting with intractable and relapsing atopic skin lesions and (or) subcutaneous mass. Patients with high levels of serum IgE and blood basophils may be prone to developing KD-associated nephritis and predict a high risk of recurrence. Early surgical removal of the mass may result in a better prognosis.
摘要：
■木村病（KD）由于其早期的稀有性和非典型症状，对临床医生提出了诊断挑战，治疗困难，容易复发或其他器官受累。
■本研究旨在通过分析临床表现来探讨肾脏受累和复发的可能相关性，实验室结果,组织病理学特征,KD的治疗数据和随访结果。
■本研究根据组织病理学诊断对1999年1月至2021年12月在两家医院诊断为KD的27例患者进行回顾性分析。
■KD主要影响男性多于女性（8：1），发病年龄为3至58岁（中位数为29.8岁）。常见的初始症状包括皮下软组织或淋巴结肿大，非特异性皮肤病变和蛋白尿。一名患者以咳嗽和咳痰为首发症状。KD患者常有高水平的血清免疫球蛋白E（IgE）和嗜碱性粒细胞，与肾脏受累和复发呈显著正相关(p<0.05)。早期肿块切除可以预防肾炎的发展，降低复发风险（p<0.05）。
■出现顽固性和复发性特应性皮肤病变和（或）皮下肿块的患者应注意KD。血清IgE和嗜碱性粒细胞水平高的患者可能容易发生KD相关性肾炎，并预测复发风险高。早期手术切除肿块可能会导致更好的预后。
■本研究旨在通过分析临床表现来探讨肾脏受累和复发的可能相关性，实验室结果,组织病理学特征,KD的治疗数据和随访结果。
■本研究根据组织病理学诊断对1999年1月至2021年12月在两家医院诊断为KD的27例患者进行回顾性分析。
■KD主要影响男性多于女性（8：1），发病年龄为3至58岁（中位数为29.8岁）。常见的初始症状包括皮下软组织或淋巴结肿大，非特异性皮肤病变和蛋白尿。一名患者以咳嗽和咳痰为首发症状。KD患者常有高水平的血清免疫球蛋白E（IgE）和嗜碱性粒细胞，与肾脏受累和复发呈显著正相关(p<0.05)。早期肿块切除可以预防肾炎的发展，降低复发风险（p<0.05）。
■出现顽固性和复发性特应性皮肤病变和（或）皮下肿块的患者应注意KD。血清IgE和嗜碱性粒细胞水平高的患者可能容易发生KD相关性肾炎，并预测复发风险高。早期手术切除肿块可能会导致更好的预后。
