PDF(Pubmed)
Abstract：
OBJECTIVE: To explore the brain mechanism of acupuncture for children with anisometropic amblyopia using the voxel-mirror homotopic connectivity (VMHC) analysis method of resting functional magnetic resonance imaging (rs-fMRI) technology based on clinical effectiveness.
METHODS: Eighty children with anisometropic monocular amblyopia were randomly divided into two groups: control (40 cases, 1 case of shedding) and acupuncture (40 cases, 1 case of shedding) groups. The control group was treated with glasses, red flash, grating, and visual stimulations, with each procedure conducted for 5min per time. Based on routine treatment, the acupuncture group underwent acupuncture of \"regulating qi and unblocking meridians to bright eyes\", Jingming (BL1), Cuanzhu (BL2), Guangming (GB37), Fengchi (GB20) acupoints were taken on both sides, with the needle kept for 30min each time. Both groups were treated once every other day, three times per week, for a total of 4wk. After the treatment, the overall curative effect of the two groups and the latency and amplitude changes of P100 wave of pattern visual-evoked potential were counted. At the same time, nine children with left eye amblyopia were randomly selected from the two groups and were scanned with rs-fMRI before and after treatment. The differences in the brain regions between the two groups were compared and analyzed with VMHC.
RESULTS: Chi-square test showed a notable difference in the total efficiency rate between the acupuncture (94.87%) and control groups (79.49%). Regarding the P100 wave latency and amplitude, the acupuncture group had significantly shorter latency and higher amplitude of P100 wave than the control group. Moreover, the VMHC values of the bilateral temporal lobe, superior temporal gyrus, and middle temporal gyrus were notably increased in the acupuncture group after treatment.
CONCLUSIONS: Acupuncture combined with conventional treatment can significantly improve the corrected visual acuity and optic nerve conduction in children with anisometropic amblyopia. Compared with the conventional treatment, the regulation of acupuncture on the functional activities of the relevant brain areas in the anterior cerebellum may be an effective acupuncture mechanism for anisometropic amblyopia.
METHODS: Eighty children with anisometropic monocular amblyopia were randomly divided into two groups: control (40 cases, 1 case of shedding) and acupuncture (40 cases, 1 case of shedding) groups. The control group was treated with glasses, red flash, grating, and visual stimulations, with each procedure conducted for 5min per time. Based on routine treatment, the acupuncture group underwent acupuncture of \"regulating qi and unblocking meridians to bright eyes\", Jingming (BL1), Cuanzhu (BL2), Guangming (GB37), Fengchi (GB20) acupoints were taken on both sides, with the needle kept for 30min each time. Both groups were treated once every other day, three times per week, for a total of 4wk. After the treatment, the overall curative effect of the two groups and the latency and amplitude changes of P100 wave of pattern visual-evoked potential were counted. At the same time, nine children with left eye amblyopia were randomly selected from the two groups and were scanned with rs-fMRI before and after treatment. The differences in the brain regions between the two groups were compared and analyzed with VMHC.
RESULTS: Chi-square test showed a notable difference in the total efficiency rate between the acupuncture (94.87%) and control groups (79.49%). Regarding the P100 wave latency and amplitude, the acupuncture group had significantly shorter latency and higher amplitude of P100 wave than the control group. Moreover, the VMHC values of the bilateral temporal lobe, superior temporal gyrus, and middle temporal gyrus were notably increased in the acupuncture group after treatment.
CONCLUSIONS: Acupuncture combined with conventional treatment can significantly improve the corrected visual acuity and optic nerve conduction in children with anisometropic amblyopia. Compared with the conventional treatment, the regulation of acupuncture on the functional activities of the relevant brain areas in the anterior cerebellum may be an effective acupuncture mechanism for anisometropic amblyopia.
摘要：
目的：基于临床效果的静息功能磁共振成像(rs-fMRI)技术的体素-镜像同源连接(VMHC)分析方法探讨针刺治疗儿童屈光参差性弱视的脑机制。
方法:80例屈光参差性单眼弱视患儿随机分为对照组(40例,脱落1例)和针刺(40例，1例脱落)组。对照组给予眼镜治疗,红色闪光,光栅,和视觉刺激，每个程序进行5min/次。在常规治疗的基础上,针灸组接受了“理气通络明目”的针灸，景明（BL1），宽竹（BL2），光明(GB37),两侧取风池（GB20）穴位，每次用针保持30min。两组均隔天治疗一次,每周三次,总共4wk。治疗后,统计两组的总体疗效以及P100模式视觉诱发电位波的潜伏期和波幅变化。同时,从两组中随机选取9例左眼弱视患儿,治疗前后进行rs-fMRI扫描。比较两组脑区的差异,并用VMHC进行分析。
结果：卡方检验显示针刺组总有效率（94.87%）与对照组（79.49%）有显著差异。关于P100波的延迟和振幅，针刺组P100波潜伏期明显短于对照组,波幅明显高于对照组。此外，双侧颞叶的VMHC值,颞上回,针刺组治疗后颞中回明显增多。
结论：针刺配合常规治疗可明显改善屈光参差性弱视患儿的矫正视力和视神经传导。与常规治疗相比,针刺对小脑前相关脑区功能活动的调节可能是治疗屈光参差性弱视的一种有效的针刺机制。
方法:80例屈光参差性单眼弱视患儿随机分为对照组(40例,脱落1例)和针刺(40例，1例脱落)组。对照组给予眼镜治疗,红色闪光,光栅,和视觉刺激，每个程序进行5min/次。在常规治疗的基础上,针灸组接受了“理气通络明目”的针灸，景明（BL1），宽竹（BL2），光明(GB37),两侧取风池（GB20）穴位，每次用针保持30min。两组均隔天治疗一次,每周三次,总共4wk。治疗后,统计两组的总体疗效以及P100模式视觉诱发电位波的潜伏期和波幅变化。同时,从两组中随机选取9例左眼弱视患儿,治疗前后进行rs-fMRI扫描。比较两组脑区的差异,并用VMHC进行分析。
结果：卡方检验显示针刺组总有效率（94.87%）与对照组（79.49%）有显著差异。关于P100波的延迟和振幅，针刺组P100波潜伏期明显短于对照组,波幅明显高于对照组。此外，双侧颞叶的VMHC值,颞上回,针刺组治疗后颞中回明显增多。
结论：针刺配合常规治疗可明显改善屈光参差性弱视患儿的矫正视力和视神经传导。与常规治疗相比,针刺对小脑前相关脑区功能活动的调节可能是治疗屈光参差性弱视的一种有效的针刺机制。
