PDF(Pubmed)
Abstract：
This study conducted a literature review to investigate the immunomodulatory effect of levamisole in both humans and farm animals. The following procedure was followed for database searching: PubMed, Google Scholar, Web of Science, and Cochrane Library. All research works were updated to September 2022. The terms used in the literature search were included: (\"levamisole\" OR \"immunity\" OR \"immune system\") AND (\"adjuvant\" OR \"fish\" OR \"poultry\" OR \"farm animal\" OR \"cattle\" OR \"sheep\"). The current review enlightens the extensive potential of levamisole as an adjuvant immunotherapeutic agent and explains its divergent applications beyond its antiparasitic use as an adjuvant, dietary supplement, immunostimulant, antiviral, and anti-cancer drug in humans and farm animals. In the articles examined, various mechanisms have been proposed for levamisole immunoprotective effects, but hormonal alteration and stress hormone reduction are indicated as the main mechanisms in various animal species.
摘要：
本研究进行了文献综述，以研究左旋咪唑在人类和农场动物中的免疫调节作用。数据库搜索遵循以下步骤:PubMed,谷歌学者，WebofScience,科克伦图书馆所有研究工作均更新至2022年9月。文献检索中使用的术语包括：（\“左旋咪唑\”或\“免疫\”或\“免疫系统\”）和（\“佐剂\”或\“鱼\”或\“家禽\”或\“农场动物\”或\“牛\”或\“绵羊\”）。当前的评论启发了左旋咪唑作为佐剂免疫治疗剂的广泛潜力，并解释了其作为佐剂的抗寄生虫用途之外的不同应用。膳食补充剂，免疫刺激剂,抗病毒，和抗癌药物在人类和农场动物。在检查的文章中，已经提出了左旋咪唑免疫保护作用的各种机制，但是激素改变和应激激素减少被认为是各种动物物种的主要机制。
