PDF(Pubmed)
Abstract：
Hepatocellular carcinoma (HCC) is a prevalent cancer worldwide. Late-stage detection, ineffective treatments, and tumor recurrence contribute to the low survival rate of the HCC. Conventional chemotherapeutic drugs, like doxorubicin (DOX), are associated with severe side effects, limited effectiveness, and tumor resistance. To improve therapeutic outcomes and minimize these drawbacks, combination therapy with natural drugs is being researched. Herein, we assessed the antitumor efficacy of Ceiba pentandra ethyl acetate extract alone and in combination with DOX against diethylnitrosamine (DENA)-induced HCC in rats. Our in vivo study significantly revealed improvement in the liver-function biochemical markers (ALT, AST, GGT, and ALP), the tumor marker (AFP-L3), and the histopathological features of the treated groups. A UHPLC-Q-TOF-MS/MS analysis of the Ceiba pentandra ethyl acetate extract enabled the identification of fifty phytomolecules. Among these are the dietary flavonoids known to have anticancer, anti-inflammatory, and antioxidant qualities: protocatechuic acid, procyanidin B2, epicatechin, rutin, quercitrin, quercetin, kaempferol, naringenin, and apigenin. Our findings highlight C. pentandra as an affordable source of phytochemicals with possible chemosensitizing effects, which could be an intriguing candidate for the development of liver cancer therapy, particularly in combination with chemotherapeutic drugs.
摘要：
肝细胞癌（HCC）是世界范围内普遍存在的癌症。后期检测，无效的治疗,肿瘤复发导致肝癌生存率低。常规化疗药物，像阿霉素（DOX），与严重的副作用有关，效果有限,和肿瘤抗性。为了改善治疗结果并最大程度地减少这些缺点，与天然药物的联合治疗正在研究中。在这里，我们评估了头孢戊酮乙酸乙酯提取物单独以及与DOX联合使用对二乙基亚硝胺（DENA）诱导的大鼠HCC的抗肿瘤功效。我们的体内研究显着揭示了肝功能生化标志物的改善（ALT，AST,GGT,和ALP），肿瘤标志物（AFP-L3），和治疗组的组织病理学特征。Seibapentandra乙酸乙酯提取物的UHPLC-Q-TOF-MS/MS分析能够鉴定50种植物分子。其中包括已知具有抗癌作用的膳食类黄酮，抗炎,和抗氧化特性：原儿茶酸，原花青素B2，表儿茶素，芦丁,槲皮苷,槲皮素,山奈酚,柚皮苷,还有芹菜素.我们的发现强调了五味子是一种负担得起的植物化学物质来源，可能具有化学增敏作用，这可能是肝癌治疗发展的一个有趣的候选者，特别是与化疗药物联合使用。
