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Abstract：
Prostate cancer (PCa) is the most prevalent cause of death in the male population worldwide. The G Protein-Coupled Estrogen Receptor (GPER) has been gaining relevance in the development of PCa. Hedgehog (Hh) pathway activation is associated with aggressiveness, metastasis, and relapse in PCa patients. To date, no studies have evaluated the crosstalk between the GPER and the Hh pathway along different group grades in PCa. We conducted an analysis of paraffin-embedded tissues derived from patients with different prognostic grade of PCa using immunohistochemistry. Expression and correlation between GPER and glioma associated oncogene homologue (GLI) transcriptional factors in the parenchyma and stroma of PCa tumors were evaluated. Our results indicate that GPER is highly expressed in the nucleus and increases with higher grade groups. Additionally, GPER\'s expression correlates with pGLI3 nuclear expression across different grade groups in PCa tissues; however, whether the receptor induces the activation of GLI transcriptional factors, or the latter modulate the expression of GPER is yet to be discovered, as well as the functional consequence of this correlation.
摘要：
前列腺癌(PCa)是全球男性人群中最普遍的死亡原因。G蛋白偶联雌激素受体（GPER）在PCa的开发中具有重要意义。Hedgehog（Hh）通路激活与侵袭性有关，转移,PCa患者复发。迄今为止,没有研究评估PCa中GPER与Hh通路沿不同组等级的串扰.我们使用免疫组织化学对来自不同PCa预后等级的患者的石蜡包埋组织进行了分析。评估了GPER和胶质瘤相关癌基因同源物（GLI）转录因子在PCa肿瘤实质和间质中的表达及其相关性。我们的结果表明，GPER在细胞核中高度表达，并随着高等级组的增加而增加。此外,GPER的表达与PCa组织中不同级别组的pGLI3核表达相关；然而，受体是否诱导GLI转录因子的激活，或后者调节GPER的表达尚未被发现，以及这种相关性的功能结果。
