Abstract：
In two separate reviews, we review the time-honored but still frequently challenging features of ovarian sex cord-stromal tumors, and also emphasize new developments including unusual morphologic appearances that, despite the relative rarity of many of the tumors, result in a disproportionate number of differential diagnostic problems, variant immunohistochemical profiles, and specific molecular and syndromic associations. These neoplasms are also of historical interest as current knowledge is still based in significant part on the contributions of 2 giants of gynecologic pathology, Dr Robert Meyer and Dr Robert E. Scully. In part I, we present the major clinical, pathologic, and genomic features of the pure ovarian stromal tumors including comments on differential diagnosis and briefly note significant historical contributions. In part II we will discuss pure sex cord and sex cord-stromal tumors.
摘要：
在两个独立的评论中，我们回顾了历史悠久但仍然经常具有挑战性的卵巢性索间质肿瘤的特征，并强调新的发展，包括不寻常的形态出现，尽管许多肿瘤相对罕见，导致不成比例的鉴别诊断问题，变异的免疫组织化学谱，以及特定的分子和综合征关联。这些肿瘤也具有历史意义，因为目前的知识仍然很大程度上基于两个妇科病理学巨人的贡献，罗伯特·迈耶博士和罗伯特·E·史卡利博士。在第一部分,我们提出了主要的临床，病理性,和纯卵巢间质瘤的基因组特征，包括对鉴别诊断的评论，并简要说明重大的历史贡献。在第二部分中，我们将讨论纯性索和性索间质肿瘤。
