PDF(Pubmed)
Abstract：
Some failures in ovary function, like folliculogenesis and oogenesis, can give rise to various infertility-associated problems, including polycystic ovary syndrome (PCOS) and premature ovarian insufficiency (POI). PCOS influences 8 to 20% of women; while POI occurs in at least 1% of all women. Regrettably, the current therapies for these diseases have not sufficiently been effective, and finding a suitable strategy is still a puzzle. One of the helpful strategies for managing and treating these disorders is understanding the contributing pathogenesis and mechanisms. Recently, it has been declared that abnormal expression of microRNAs (miRNAs), as a subset of non-coding RNAs, is involved in the pathogenesis of reproductive diseases. Among the miRNAs, the roles of miRNA-21 in the pathogenesis of PCOS and POI have been highlighted in some documents; hence, the purpose of this mini-review was to summarize the evidences in conjunction with the functions of this miRNA and other effective microRNAs in the normal or abnormal functions of the ovary (i.e., PCOS and POI) with a mechanistic insight.
摘要：
卵巢功能有些衰竭,比如卵泡发生和卵子发生，会引起各种不孕症相关的问题，包括多囊卵巢综合征（PCOS）和卵巢早衰（POI）。PCOS影响8％至20％的女性;而POI发生在至少1％的女性中。遗憾的是,目前对这些疾病的治疗还不够有效，找到合适的策略仍然是一个难题。管理和治疗这些疾病的有用策略之一是了解其发病机理和机制。最近,已经宣布microRNAs（miRNAs）的异常表达，作为非编码RNA的子集，参与生殖疾病的发病机制。在miRNA中，miRNA-21在PCOS和POI发病机制中的作用已在一些文献中得到强调;本小型综述的目的是总结与该miRNA和其他有效microRNAs在卵巢正常或异常功能中的功能相关的证据（即，PCOS和POI)具有机械洞察力。
