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Abstract：
OBJECTIVE: Acknowledging the associated risk factors may have a positive impact on reducing the incidence of ectopic pregnancy (EP). In recent years, body mass index (BMI) has been mentioned in research. However, few studies are available and controversial on the relationship between EP and BMI.
METHODS: We retrospectively studied the EP women as a case group and the deliveries as a control group in the central hospital of Wuhan during 2017 ~ 2021. χ2 test of variables associated with ectopic pregnancy was performed to find differences. Univariate and multivariate binary logistic regression analysis was conducted to analyze the association of the variables of age, parity, history of induced abortion, history of ectopic pregnancy, history of spontaneous abortion, history of appendectomy surgery and BMI (< 18.5 kg/m2, 18.5 ~ 24.9 kg/m2, 25 kg/m2 ~ 29.9 kg/m2, ≥ 30 kg /m2) with EP.
RESULTS: They were 659 EP and 1460 deliveries. The variables of age, parity, history of induced abortion, history of ectopic pregnancy and BMI were different significantly(P < 0.05). Multivariate analysis showed that the variables of age > 35 years old [(OR (Odds Ratio), 5.415; 95%CI (Confidence Interval), 4.006 ~ 7.320, P < 0.001], history of ectopic pregnancy (OR, 3.944; 95%CI, 2.405 ~ 6.467; P < 0.001), history of induced abortion(OR, 3.365; 95%CI, 2.724 ~ 4.158, P < 0.001) and low BMI (< 18.5 kg/m2) (OR, 1.929; 95%CI, 1.416 ~ 2.628, P < 0.001])increased the risk of EP.
CONCLUSIONS: The history of ectopic pregnancy, history of induced abortion and age > 35 years old were the risk factors with EP. In addition to these traditional factors, we found low BMI (< 18.5 kg/m2) with women may increase the risk to EP.
METHODS: We retrospectively studied the EP women as a case group and the deliveries as a control group in the central hospital of Wuhan during 2017 ~ 2021. χ2 test of variables associated with ectopic pregnancy was performed to find differences. Univariate and multivariate binary logistic regression analysis was conducted to analyze the association of the variables of age, parity, history of induced abortion, history of ectopic pregnancy, history of spontaneous abortion, history of appendectomy surgery and BMI (< 18.5 kg/m2, 18.5 ~ 24.9 kg/m2, 25 kg/m2 ~ 29.9 kg/m2, ≥ 30 kg /m2) with EP.
RESULTS: They were 659 EP and 1460 deliveries. The variables of age, parity, history of induced abortion, history of ectopic pregnancy and BMI were different significantly(P < 0.05). Multivariate analysis showed that the variables of age > 35 years old [(OR (Odds Ratio), 5.415; 95%CI (Confidence Interval), 4.006 ~ 7.320, P < 0.001], history of ectopic pregnancy (OR, 3.944; 95%CI, 2.405 ~ 6.467; P < 0.001), history of induced abortion(OR, 3.365; 95%CI, 2.724 ~ 4.158, P < 0.001) and low BMI (< 18.5 kg/m2) (OR, 1.929; 95%CI, 1.416 ~ 2.628, P < 0.001])increased the risk of EP.
CONCLUSIONS: The history of ectopic pregnancy, history of induced abortion and age > 35 years old were the risk factors with EP. In addition to these traditional factors, we found low BMI (< 18.5 kg/m2) with women may increase the risk to EP.
摘要：
目的：认识到相关危险因素可能对降低异位妊娠（EP）的发生率具有积极影响。近年来,研究中提到了体重指数(BMI)。然而,关于EP和BMI之间关系的研究很少，并且存在争议。
方法：以2017~2021年武汉市中心医院收治的EP产妇为病例组，以分娩产妇为对照组进行回顾性研究。对与异位妊娠相关的变量进行χ2检验以发现差异。进行单因素和多因素二元logistic回归分析,奇偶校验，人工流产史,异位妊娠史,自然流产史,阑尾切除术史和BMI（<18.5kg/m2，18.5〜24.9kg/m2，25kg/m2〜29.9kg/m2，≥30kg/m2）合并EP。
结果：分别为659例EP和1460例。年龄的变量，奇偶校验，人工流产史,宫外孕病史和BMI差异有统计学意义(P<0.05)。多变量分析表明，年龄>35岁[（OR（赔率比），5.415；95CI(置信区间)，4.006~7.320,P<0.001],异位妊娠史（OR，3.944；95CI，2.405~6.467；P<0.001），人工流产史（OR，3.365；95CI，2.724~4.158，P<0.001）和低BMI（<18.5kg/m2）（OR，1.929；95CI，1.416~2.628，P<0.001]）增加EP的风险。
结论：异位妊娠史，人工流产史和年龄>35岁是EP的危险因素。除了这些传统因素，我们发现低BMI(<18.5kg/m2)的女性可能会增加EP的风险.
方法：以2017~2021年武汉市中心医院收治的EP产妇为病例组，以分娩产妇为对照组进行回顾性研究。对与异位妊娠相关的变量进行χ2检验以发现差异。进行单因素和多因素二元logistic回归分析,奇偶校验，人工流产史,异位妊娠史,自然流产史,阑尾切除术史和BMI（<18.5kg/m2，18.5〜24.9kg/m2，25kg/m2〜29.9kg/m2，≥30kg/m2）合并EP。
结果：分别为659例EP和1460例。年龄的变量，奇偶校验，人工流产史,宫外孕病史和BMI差异有统计学意义(P<0.05)。多变量分析表明，年龄>35岁[（OR（赔率比），5.415；95CI(置信区间)，4.006~7.320,P<0.001],异位妊娠史（OR，3.944；95CI，2.405~6.467；P<0.001），人工流产史（OR，3.365；95CI，2.724~4.158，P<0.001）和低BMI（<18.5kg/m2）（OR，1.929；95CI，1.416~2.628，P<0.001]）增加EP的风险。
结论：异位妊娠史，人工流产史和年龄>35岁是EP的危险因素。除了这些传统因素，我们发现低BMI(<18.5kg/m2)的女性可能会增加EP的风险.
