Abstract：
Heart failure with preserved ejection fraction (HFpEF) is increasingly recognised and diagnosed in clinical practice, a trend driven by an ageing population and a rise in contributing comorbidities, such as obesity and diabetes. Representing at least half of all heart failure cases, HFpEF is recognised as a complex clinical syndrome. Its diagnosis and management are challenging due to its diverse pathophysiology, varied epidemiological patterns, and evolving diagnostic and treatment approaches. This Seminar synthesises the latest insights on HFpEF, integrating findings from recent clinical trials, epidemiological research, and the latest guideline recommendations. We delve into the definition, pathogenesis, epidemiology, diagnostic criteria, and management strategies (non-pharmacological and pharmacological) for HFpEF. We highlight ongoing clinical trials and future developments in the field. Specifically, this Seminar offers practical guidance tailored for primary care practitioners, generalists, and cardiologists who do not specialise in heart failure, simplifying the complexities in the diagnosis and management of HFpEF. We provide practical, evidence-based recommendations, emphasising the importance of addressing comorbidities and integrating the latest pharmacological treatments, such as SGLT2 inhibitors.
摘要：
射血分数保留的心力衰竭（HFpEF）在临床实践中得到越来越多的认可和诊断。人口老龄化和共患疾病增加的趋势，比如肥胖和糖尿病。代表至少一半的心力衰竭病例，HFpEF被认为是一种复杂的临床综合征。由于其不同的病理生理学，其诊断和管理具有挑战性，不同的流行病学模式，以及不断发展的诊断和治疗方法。本次研讨会综合了HFpEF的最新见解，整合最近临床试验的结果，流行病学研究,和最新的指南建议。我们深入研究定义，发病机制，流行病学,诊断标准,以及HFpEF的管理策略（非药物和药物）。我们重点介绍了该领域正在进行的临床试验和未来的发展。具体来说,这个研讨会提供了为初级保健医生量身定制的实用指导，通才,和不专门研究心力衰竭的心脏病专家，简化HFpEF诊断和管理的复杂性。我们提供实用，基于证据的建议，强调解决合并症和整合最新药物治疗的重要性，如SGLT2抑制剂。
