Abstract：
The development of central nervous system (CNS) can form perceptual, memory, and cognitive functions, while injuries to CNS often lead to severe neurological dysfunction and even death. As one of the prevalent post-translational modifications (PTMs), O-GlcNAcylation has recently attracted great attentions due to its functions in regulating the activity, subcellular localization, and stability of target proteins. It has been indicated that O-GlcNAcylation could interact with phosphorylation, ubiquitination, and methylation to jointly regulate the function and activity of proteins. Furthermore, a growing number of studies have suggested that O-GlcNAcylation played an important role in the CNS. During development, O-GlcNAcylation participated in the neurogenesis, neuronal development, and neuronal function. In addition, O-GlcNAcylation was involved in the progress of CNS injuries including ischemic stroke, subarachnoid hemorrhage (SAH), and intracerebral hemorrhage (ICH) and played a crucial role in the improvement of brain damage such as attenuating cognitive impairment, inhibiting neuroinflammation, suppressing endoplasmic reticulum (ER) stress, and maintaining blood-brain barrier (BBB) integrity. Therefore, O-GlcNAcylation showed great promise as a potential target in CNS development and injuries. In this article, we presented a review highlighting the role of O-GlcNAcylation in CNS development and injuries. Hence, on the basis of these properties and effects, intervention with O-GlcNAcylation may be developed as therapeutic agents for CNS diseases.
摘要：
中枢神经系统(CNS)的发育可以形成知觉,记忆,和认知功能，而中枢神经系统的损伤往往会导致严重的神经功能障碍甚至死亡。作为一种普遍的翻译后修饰（PTM），O-GlcNAcylation由于其在调节活性方面的作用最近引起了极大的关注，亚细胞定位，和靶蛋白的稳定性。已经表明O-GlcNAcylation可以与磷酸化相互作用，泛素化，和甲基化共同调节蛋白质的功能和活性。此外，越来越多的研究表明O-GlcNAcylation在中枢神经系统中起着重要作用。在开发过程中,O-GlcNAcylation参与了神经发生，神经元发育，和神经元功能。此外,O-GlcNAcylation参与CNS损伤的进展，包括缺血性卒中，蛛网膜下腔出血(SAH),和脑出血（ICH），并在改善脑损伤，如减轻认知障碍，发挥了关键作用，抑制神经炎症，抑制内质网（ER）应激，维持血脑屏障(BBB)完整性。因此,O-GlcNAcylation作为CNS发育和损伤的潜在靶标显示出巨大的希望。在这篇文章中,我们对O-GlcNAcylation在中枢神经系统发育和损伤中的作用进行了综述.因此，根据这些性质和效果，O-GlcNAcylation的干预可能被开发为CNS疾病的治疗剂。
