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Abstract：
To describe papillitis as a clinical phenotype of IgLON5 autoimmunity.
We retrospectively reviewed patients with IgLON5 autoimmunity who had optic neuropathy, optic neuritis, or optic disc edema. Sera from patients with recurrent papillitis were tested for IgLON5 antibodies.
We found two elderly males presenting with papillitis in the presence of IgLON5 antibodies. CSF pleocytosis was present and partial vision improvement occurred in one patient despite immunotherapy. Sera from 18 patients with recurrent papillitis were negative for IgLON5 antibodies.
Papillitis could be a manifestation of IgLON5 disease, with or without accompanying cognitive, sleep, and movement disorders.
We retrospectively reviewed patients with IgLON5 autoimmunity who had optic neuropathy, optic neuritis, or optic disc edema. Sera from patients with recurrent papillitis were tested for IgLON5 antibodies.
We found two elderly males presenting with papillitis in the presence of IgLON5 antibodies. CSF pleocytosis was present and partial vision improvement occurred in one patient despite immunotherapy. Sera from 18 patients with recurrent papillitis were negative for IgLON5 antibodies.
Papillitis could be a manifestation of IgLON5 disease, with or without accompanying cognitive, sleep, and movement disorders.
摘要：
目的：将乳头炎描述为IgLON5自身免疫的临床表型。
方法：我们回顾性分析了IgLON5自身免疫性视神经病变患者，视神经炎,或视神经盘水肿。对复发性乳头炎患者的血清进行了IgLON5抗体测试。
结果：我们发现两名老年男性在存在IgLON5抗体时出现乳头状炎。尽管进行了免疫疗法，但一名患者仍存在CSF细胞增多，部分视力改善。18例复发性乳头炎患者的血清对IgLON5抗体呈阴性。
结论：乳头炎可能是IgLON5疾病的表现，有或没有伴随的认知，睡眠,和运动障碍。
方法：我们回顾性分析了IgLON5自身免疫性视神经病变患者，视神经炎,或视神经盘水肿。对复发性乳头炎患者的血清进行了IgLON5抗体测试。
结果：我们发现两名老年男性在存在IgLON5抗体时出现乳头状炎。尽管进行了免疫疗法，但一名患者仍存在CSF细胞增多，部分视力改善。18例复发性乳头炎患者的血清对IgLON5抗体呈阴性。
结论：乳头炎可能是IgLON5疾病的表现，有或没有伴随的认知，睡眠,和运动障碍。
