Abstract：
As a thermoplastic and bioinert polymer, polyether ether ketone (PEEK) serves as spine implants, femoral stems, cranial implants, and joint arthroplasty implants due to its mechanical properties resembling the cortical bone, chemical stability, and radiolucency. Although there are standards and antibiotic treatments for infection control during and after surgery, the infection risk is lowered but can not be eliminated. The antibacterial properties of PEEK implants should be improved to provide better infection control. This review includes the strategies for enhancing the antibacterial properties of PEEK in four categories: immobilization of functional materials and functional groups, forming nanocomposites, changing surface topography, and coating with antibacterial material. The measuring methods of antibacterial properties of the current studies of PEEK are explained in detail under quantitative, qualitative, andin vivomethods. The mechanisms of bacterial inhibition by reactive oxygen species generation, contact killing, trap killing, and limited bacterial adhesion on hydrophobic surfaces are explained with corresponding antibacterial compounds or techniques. The prospective analysis of the current studies is done, and dual systems combining osteogenic and antibacterial agents immobilized on the surface of PEEK are found the promising solution for a better implant design.
摘要：
作为热塑性和生物惰性聚合物，聚醚醚酮（PEEK）作为脊柱植入物，股骨茎,颅骨植入物,和关节成形术植入物，由于其机械性能类似于皮质骨，化学稳定性,和射线可透性。尽管手术期间和手术后有控制感染的标准和抗生素治疗方法，感染风险降低但无法消除。应改善PEEK植入物的抗菌性能，以提供更好的感染控制。本文综述了增强PEEK抗菌性能的策略，包括四类：固定功能材料和官能团，形成纳米复合材料，改变表面形貌，和抗菌材料涂层。目前PEEK的抗菌性能的测量方法进行了详细的解释,定性，和体内方法。通过活性氧（ROS）的产生抑制细菌的机制，接触杀戮,陷阱杀死，用相应的抗菌化合物或技术解释了疏水性表面上有限的细菌粘附。对目前的研究进行了前瞻性分析，结合固定在PEEK表面上的成骨和抗菌剂的双重系统被发现是更好的植入物设计的有希望的解决方案。
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