Abstract：
UNASSIGNED: To compare the hemodynamic performance of three (Bottom Up non-ballet, Top-Down non-ballet, Top Down ballet) idealized stent graft configurations used during endovascular repair of abdominal aortic aneurysms, under the influence of various rheological models.
UNASSIGNED: Ten rheological models are assumed and a commercial finite volume solver is employed for the simulation of blood flow under realistic boundary conditions. An appropriate mesh convergence study is performed and five hemodynamic variables are computed: the time average wall shear stress (TAWSS), oscillatory shear index (OSI), relative residence time (RRT), endothelial cell activation potential (ECAP) and displacement force (DF) for all three configurations.
UNASSIGNED: The choice of blood flow model may affect results, but does not constitute a significant determinant on the overall performance of the assumed stent grafts. On the contrary, stent graft geometry has a major effect. Specifically, the Bottom Up non-ballet type is characterized by the least favorable performance presenting the lowest TAWSS and the highest OSI, RRT and ECAP values. On the other hand, the Top Down ballet type presents hemodynamic advantages yielding the highest TAWSS and lowest OSI, RRT and ECAP average values. Furthermore, the ballet type is characterized by the lowest DF, although differences observed are small and their clinical relevance uncertain.
UNASSIGNED: The effect of the assumed rheological model on the overall performance of the grafts is not significant. It is thus relatively safe to claim that it is the type of stent graft that determines its overall performance rather than the adopted blood flow model.
UNASSIGNED: Ten rheological models are assumed and a commercial finite volume solver is employed for the simulation of blood flow under realistic boundary conditions. An appropriate mesh convergence study is performed and five hemodynamic variables are computed: the time average wall shear stress (TAWSS), oscillatory shear index (OSI), relative residence time (RRT), endothelial cell activation potential (ECAP) and displacement force (DF) for all three configurations.
UNASSIGNED: The choice of blood flow model may affect results, but does not constitute a significant determinant on the overall performance of the assumed stent grafts. On the contrary, stent graft geometry has a major effect. Specifically, the Bottom Up non-ballet type is characterized by the least favorable performance presenting the lowest TAWSS and the highest OSI, RRT and ECAP values. On the other hand, the Top Down ballet type presents hemodynamic advantages yielding the highest TAWSS and lowest OSI, RRT and ECAP average values. Furthermore, the ballet type is characterized by the lowest DF, although differences observed are small and their clinical relevance uncertain.
UNASSIGNED: The effect of the assumed rheological model on the overall performance of the grafts is not significant. It is thus relatively safe to claim that it is the type of stent graft that determines its overall performance rather than the adopted blood flow model.
摘要：
■要比较三种（自下而上非芭蕾舞，自上而下的非芭蕾舞,自上而下的芭蕾舞）在腹主动脉瘤的血管内修复中使用的理想化支架移植物配置，在各种流变模型的影响下。
■假定了十个流变模型，并采用了商业有限体积求解器，以模拟现实边界条件下的血流。进行了适当的网格收敛性研究，并计算了五个血液动力学变量：时间平均壁切应力（TAWSS），振荡剪切指数(OSI)，相对停留时间（RRT），所有三种构型的内皮细胞激活电位（ECAP）和位移力（DF）。
■血流模型的选择可能会影响结果，但并不构成对假定支架移植物整体性能的重要决定因素。相反,支架移植物的几何形状具有主要影响。具体来说,自下而上的非芭蕾类型的特点是表现最差，表现出最低的TAWSS和最高的OSI，RRT和ECAP值。另一方面,TopDown芭蕾舞类型具有血液动力学优势，可产生最高的TAWSS和最低的OSI，RRT和ECAP平均值。此外，芭蕾舞类型的特点是DF最低，尽管观察到的差异很小，并且其临床相关性不确定。
■假定的流变模型对移植物的整体性能的影响并不显着。因此，相对安全的说法是，决定其整体性能的是支架移植物的类型，而不是所采用的血流模型。
■假定了十个流变模型，并采用了商业有限体积求解器，以模拟现实边界条件下的血流。进行了适当的网格收敛性研究，并计算了五个血液动力学变量：时间平均壁切应力（TAWSS），振荡剪切指数(OSI)，相对停留时间（RRT），所有三种构型的内皮细胞激活电位（ECAP）和位移力（DF）。
■血流模型的选择可能会影响结果，但并不构成对假定支架移植物整体性能的重要决定因素。相反,支架移植物的几何形状具有主要影响。具体来说,自下而上的非芭蕾类型的特点是表现最差，表现出最低的TAWSS和最高的OSI，RRT和ECAP值。另一方面,TopDown芭蕾舞类型具有血液动力学优势，可产生最高的TAWSS和最低的OSI，RRT和ECAP平均值。此外，芭蕾舞类型的特点是DF最低，尽管观察到的差异很小，并且其临床相关性不确定。
■假定的流变模型对移植物的整体性能的影响并不显着。因此，相对安全的说法是，决定其整体性能的是支架移植物的类型，而不是所采用的血流模型。
