PDF(Pubmed)
Abstract：
Spindle cell neoplasms arising in the head and neck may be challenging to recognize due to their relative rarity. While underlying molecular alterations are increasingly elucidated, testing for these features may not be readily available. In most cases, combinations of key morphologic features and diagnostic immunohistochemical markers can be used to replace molecular diagnostics. Conversely, some molecular alterations and expression of their surrogate biomarkers are not specific for any one entity, and it is important to recognize these to avoid diagnostic pitfalls. In this review, we discuss both old and new spindle cell tumors of the sinonasal tract, with an emphasis on histologic features and clinically relevant immunohistochemical markers serving as surrogate markers for underlying genomic alterations.
摘要：
由于头颈部出现的梭形细胞肿瘤相对罕见，因此可能难以识别。虽然潜在的分子改变越来越被阐明，这些功能的测试可能不容易获得。在大多数情况下,关键形态学特征和诊断性免疫组织化学标记的组合可用于替代分子诊断。相反，一些分子改变和他们的替代生物标志物的表达对任何一个实体都不是特异性的，重要的是要认识到这些，以避免诊断陷阱。在这次审查中,我们讨论了鼻腔鼻窦的新旧梭形细胞肿瘤，强调组织学特征和临床相关的免疫组织化学标记，作为潜在基因组改变的替代标记。
