Abstract：
MicroRNAs (miRNA) are small and conserved noncoding RNA molecules that regulate gene expression at the posttranscriptional level. These groups of RNAs are crucial in various cellular processes, especially in mediating disease pathogenesis, particularly cancer. The dysregulation of miRNAs was reported in many cancer types, including nasopharyngeal cancer (NPC), which is a malignant tumor of the nasopharynx. In this review, miRNAs involvement in crucial signaling pathways associated with NPC such as PTEN/PI3K/AKT, TGFβ/SMAD, RAS/MAPK, Wnt/β-catenin and pRB-E2F was investigated. miRNAs could function as tumor suppressor-miR or onco-miR in NPC profoundly influenced cell cycle, apoptosis, proliferation, migration, and metastasis. This comprehensive review of current literature provided a thorough profile of miRNAs and their interplay with the aforementioned signaling pathways in NPC. Understanding these molecular interactions could remarkably impact the diagnosis, prognosis, and therapeutic strategies for NPC.
摘要：
MicroRNAs(miRNA)是在转录后水平调控基因表达的小且保守的非编码RNA分子。这些RNA在各种细胞过程中至关重要，特别是在介导疾病的发病机制中，尤其是癌症。miRNA的失调被报道在许多癌症类型中，包括鼻咽癌（NPC），这是一种鼻咽部恶性肿瘤。在这次审查中,miRNA参与与NPC相关的关键信号通路，如PTEN/PI3K/AKT，TGFβ/SMAD,RAS/MAPK,研究了Wnt/β-连环蛋白和pRB-E2F。miRNA在鼻咽癌中可以作为肿瘤抑制miR或onco-miR，深刻影响细胞周期，凋亡，扩散,迁移,和转移。对当前文献的全面回顾提供了miRNA的全面概况及其与上述NPC信号通路的相互作用。了解这些分子相互作用会显著影响诊断，预后,和NPC的治疗策略。
