Abstract：
Performing efficient wound management is essential for infected diabetic wounds due to the complex pathology. Flexible electronics have been recognized as one of the promising solutions for wound management. Herein, a kind of skin-adhesive and self-healing flexible bioelectronic was developed, which could be employed as a diagnostic wound dressing to record diabetic wound healing and monitor electrophysiological signals of the patients. The flexible substrate of diagnostic wound dressings showed excellent tissue adhesive (to various substrates including biological samples), self-healing (fracture strength restores by 96%), and intrinsic antibacterial properties (antibacterial ratio >96% against multidrug-resistant bacteria). The diagnostic wound dressings could record the glucose level (1-30 mM), pH values (4-7), and body temperature (18.8-40.0 °C) around the infected diabetic wounds. Besides, the dressings could help optimize treatment strategies based on electrophysiological signals of patients monitored in real-time. This study contributes to developing flexible bioelectronics for the diagnosis and management of diabetic wounds.
摘要：
由于复杂的病理，进行有效的伤口管理对于感染的糖尿病伤口至关重要。柔性电子设备已被认为是伤口处理的有希望的解决方案之一。在这里，开发了一种皮肤粘附和自我修复的柔性生物电子，可以用作诊断伤口敷料来记录糖尿病伤口愈合并监测患者的电生理信号。诊断伤口敷料的柔性基底显示出优异的组织粘附性（对包括生物样品在内的各种基底），自我修复（断裂强度恢复96%），和固有的抗菌特性（对多重耐药细菌的抗菌率>96％）。诊断伤口敷料可以记录葡萄糖水平（1-30mM），pH值（4-7），和感染的糖尿病伤口周围的体温（18.8-40.0°C）。此外,敷料可以根据患者的电生理信号实时监测，帮助优化治疗策略。这项研究有助于开发用于诊断和管理糖尿病伤口的柔性生物电子学。
