PDF(Pubmed)
Abstract：
Six new polyketides, which includes three new lactones (talarotones A-C) (1-3), one new polyketide (talarotide A) (4), two new polyenes (talaroyenes A, B) (5, 6), together with one new meroterpenoid (talaropenoid A) (7) and 13 known compounds (8-20) were isolated from the mangrove-derived fungus Talaromyces flavus TGGP35. The structure and configuration of the compounds 1-7 were elucidated from the data obtained from HR-ESI-MS, IR, 1D/2D NMR spectroscopy, Mo2 (OAc)4-induced electronic circular dichroism (ECD), CD spectroscopy, and modified Mosher\'s method. Compounds 5 and 20 displayed antioxidant activity with IC50 values of 0.40 and 1.36 mM, respectively. Compounds 3, 6, 11, 16, and 17 displayed cytotoxic activity against human cancer cells Hela, A549, and had IC50 values ranging from 28.89 to 62.23 μM. Compounds 7, 10-12, and 14-18 exhibited moderate or potent anti-insect activity against newly hatched larvae of Helicoverpa armigera Hubner, with IC50 values in the range 50-200 μg/mL. Compound 18 showed antibacterial activity against Ralstonia solanacearum with the MIC value of 50 μg/mL.
摘要：
六种新的聚酮化合物，其中包括三个新的内酯（talarotonesA-C）（1-3），一种新的聚酮化合物（talarotideA）（4），两种新的多烯(talaroyenesA，B)(5,6),从红树林衍生的真菌TalaromycesflavusTGGP35中分离出一种新的类黄酮类化合物（talaropenoidA）（7）和13种已知化合物（8-20）。从HR-ESI-MS获得的数据阐明了化合物1-7的结构和构型，IR,1D/2DNMR光谱，Mo2（OAc）4诱导的电子圆二色性（ECD），CD光谱学,并修改了Mosher的方法。化合物5和20表现出抗氧化活性，IC50值为0.40和1.36mM，分别。化合物3、6、11、16和17显示出对人类癌细胞Hela，A549,并且具有在28.89至62.23μM范围内的IC50值。化合物7、10-12和14-18对新孵化的棉铃虫Hubner幼虫表现出中等或有效的抗虫活性，IC50值在50-200μg/mL范围内。化合物18对青枯菌具有抗菌活性,MIC值为50μg/mL。
