PDF(Pubmed)
Abstract：
UNASSIGNED: Since pregnancy is considered one of the major risk factors of cerebral venous thrombosis (CVT), the safety of pregnancy in women of childbearing age and a previous history of CVT, is concerning in terms of prevention, family planning, and management. This study aims to estimate the prevalence of pregnancies among women of childbearing age with previous CVT, evaluate the pregnancy-associated risk of CVT recurrence, and explore the maternal and fetal outcomes among CVT women in comparison with pregnant women without a history of CVT.
UNASSIGNED: A retrospective, case-control study was conducted at the Obstetrics Departments of King Fahad Medical City Hospital, Saudi Arabia. It included all women with a history of CVT diagnosed in the last 5 years (cases), as well as CVT history-free pregnant women (control). The prevalence of pregnancy after CVT was estimated and the prepartum and postpartum parameters of the two groups were compared.
UNASSIGNED: Fifty women with CVT and 100 controls were included. Among the 50 CVT cases, 28 (56.0%) have been pregnant. The incidence of pre-eclampsia was significantly more frequent in CVT women (7.1% vs. 0.0%, p = 0.047); however, only one case of deep vein thrombosis (3.6%) was reported in CVT patients versus none in controls (p = 0.219). CVT women delivered at a lower gestational age (mean [SD] = 36.9 [3.5] weeks) compared with controls (38.3 [1.4] weeks) (p = 0.006). No significant differences in other pregnancy or delivery outcomes were observed between the two groups.
UNASSIGNED: More than half of women of childbearing age with a history of CVT opt for pregnancy after the CVT episode, with no major additional risk for pre or postpartum complications.
UNASSIGNED: A retrospective, case-control study was conducted at the Obstetrics Departments of King Fahad Medical City Hospital, Saudi Arabia. It included all women with a history of CVT diagnosed in the last 5 years (cases), as well as CVT history-free pregnant women (control). The prevalence of pregnancy after CVT was estimated and the prepartum and postpartum parameters of the two groups were compared.
UNASSIGNED: Fifty women with CVT and 100 controls were included. Among the 50 CVT cases, 28 (56.0%) have been pregnant. The incidence of pre-eclampsia was significantly more frequent in CVT women (7.1% vs. 0.0%, p = 0.047); however, only one case of deep vein thrombosis (3.6%) was reported in CVT patients versus none in controls (p = 0.219). CVT women delivered at a lower gestational age (mean [SD] = 36.9 [3.5] weeks) compared with controls (38.3 [1.4] weeks) (p = 0.006). No significant differences in other pregnancy or delivery outcomes were observed between the two groups.
UNASSIGNED: More than half of women of childbearing age with a history of CVT opt for pregnancy after the CVT episode, with no major additional risk for pre or postpartum complications.
摘要：
■由于怀孕被认为是脑静脉血栓形成（CVT）的主要危险因素之一，育龄妇女怀孕的安全性和既往CVT史，在预防方面，计划生育,和管理。这项研究旨在估计以前患有CVT的育龄妇女的妊娠患病率，评估妊娠相关的CVT复发风险，并与无CVT病史的孕妇进行比较，探讨CVT妇女的母婴结局。
■回顾，病例对照研究在法赫德国王医疗城医院产科进行，沙特阿拉伯。它包括在过去5年中诊断出的所有有CVT病史的女性（病例），以及无CVT病史的孕妇（对照）。评估CVT后的妊娠患病率，并比较两组的产前和产后参数。
■包括50名患有CVT的女性和100名对照。在50个CVT案例中，28人（56.0％）怀孕。在CVT妇女中，先兆子痫的发生率明显更高（7.1％vs.0.0%,p=0.047)；然而，在CVT患者中仅报告了1例(3.6%)深静脉血栓形成,对照组则无(p=0.219).与对照组（38.3[1.4]周）相比，CVT妇女的胎龄较低（平均[SD]=36.9[3.5]周）（p=0.006）。两组之间在其他妊娠或分娩结局方面没有显着差异。
■超过一半有CVT病史的育龄妇女在CVT发作后选择怀孕，没有发生产前或产后并发症的主要额外风险。
■回顾，病例对照研究在法赫德国王医疗城医院产科进行，沙特阿拉伯。它包括在过去5年中诊断出的所有有CVT病史的女性（病例），以及无CVT病史的孕妇（对照）。评估CVT后的妊娠患病率，并比较两组的产前和产后参数。
■包括50名患有CVT的女性和100名对照。在50个CVT案例中，28人（56.0％）怀孕。在CVT妇女中，先兆子痫的发生率明显更高（7.1％vs.0.0%,p=0.047)；然而，在CVT患者中仅报告了1例(3.6%)深静脉血栓形成,对照组则无(p=0.219).与对照组（38.3[1.4]周）相比，CVT妇女的胎龄较低（平均[SD]=36.9[3.5]周）（p=0.006）。两组之间在其他妊娠或分娩结局方面没有显着差异。
■超过一半有CVT病史的育龄妇女在CVT发作后选择怀孕，没有发生产前或产后并发症的主要额外风险。
