Abstract：
Mounting evidence suggests that metal/metalloid exposure is related to the adverse health effects. Our prior investigation revealed a positive relation between the plasma level of microRNA-4286 (miR-4286) and an increased risk of developing acute coronary syndrome (ACS). However, it is a lack of studies evaluating the connection between metal/metalloid exposure and miRNA expression on ACS. In the prospective Dongfeng-Tongji cohort, we performed a nested case-control study. A total of 480 ACS and 480 controls were carefully selected based on similar age, sex, and blood collection time. Using inductively coupled plasma mass spectrometry, we assessed the plasma concentrations of 24 different metals. Quantitative real-time polymerase chain reaction was used to analyze the plasma miR-4286. We examined the relations of plasma metals with miR-4286 levels, the incidence of ACS, and the potential interactions. Using the multivariate conditional logistic regression models, we observed that the adjusted odds ratios (95% confidence intervals [CI]) for incident ACS were 1.79 (1.03, 3.12; P-trend = 0.03), 0.60 (0.41, 0.87; P-trend = 0.008), and 0.66 (0.46, 0.93; P-trend = 0.02), when comparing the extreme tertiles of aluminum, rubidium, and selenium, respectively. There was a relation between the concentration of rubidium in plasma and a decrease in the level of plasma miR-4286 (percent difference [95% CI]: -13.36% [-22.74%, -2.83%]; P-trend = 0.01). Both multiplicative (P interaction = 0.009) and additive interactions (relative excess risk due to interaction [95% CI]: 0.82 [0.59, 1.06]) were noted in our observation regarding the relationship between plasma aluminum and miR-4286 in incident ACS. The findings indicated that plasma aluminum was positively while plasma rubidium and selenium were negatively linked to an increased risk of developing ACS. Plasma aluminum exposure and plasma miR-4286 expression might synergistically affect the incident ACS risk. Controlling aluminum exposure was important for ACS prevention, especially for individuals with high expression of plasma miR-4286.
摘要：
越来越多的证据表明，金属/类金属接触与不良健康影响有关。我们先前的研究显示血浆microRNA-4286（miR-4286）水平与急性冠脉综合征（ACS）的风险增加之间存在正相关。然而,缺乏评估ACS中金属/类金属暴露与miRNA表达之间联系的研究。在未来的东风-同济队列中，我们进行了一项巢式病例对照研究.总共480个ACS和480个对照根据相似的年龄仔细选择，性别,采血时间使用电感耦合等离子体质谱法，我们评估了24种不同金属的血浆浓度.定量实时聚合酶链反应用于分析血浆miR-4286。我们检查了血浆金属与miR-4286水平的关系，ACS的发病率，和潜在的相互作用。使用多元条件逻辑回归模型，我们观察到，调整后的优势比（95％置信区间[CI]）为1.79（1.03，3.12；P趋势=0.03），0.60（0.41，0.87；P趋势=0.008），和0.66(0.46，0.93；P趋势=0.02)，当比较铝的极端三元率时，铷,还有硒,分别。血浆中铷的浓度与血浆miR-4286水平的降低之间存在关系（百分比差异[95％CI]：-13.36％[-22.74％，-2.83%]；P趋势=0.01）。在我们关于血浆铝和miR-4286之间的关系的观察中，我们注意到了倍增（P相互作用=0.009）和加性相互作用（由于相互作用[95％CI]：0.82[0.59，1.06]）。研究结果表明，血浆铝呈正相关，而血浆铷和硒与患ACS的风险增加负相关。血浆铝暴露和血浆miR-4286表达可能协同影响ACS发病风险。控制铝暴露对于ACS的预防很重要，特别是对于血浆miR-4286高表达的个体。
