Abstract：
Over the past decade, extreme temperature events have become more frequent and longer in duration. Previous studies on the association between extreme cold events (ECEs) and congenital heart defects (CHDs) are few and inconsistent. We conducted a national multicenter study in 1313 hospitals in 26 provinces in China and collected a total of 14 808 high CHD-risk participants from 2013 to 2021. We evaluated the ECEs experienced by each pregnant women during the embryonic period (3-8 weeks). The results indicated that ECEs experienced by pregnant women during the embryonic period were associated with the development of fetal CHD and were more strongly associated with some specific fetal CHD subtypes, such as pulmonary stenosis, pulmonary atresia, and tetralogy of Fallot. Of the CHD burden, 2.21% (95% CI: 1.43, 2.99%)-2.40% (95% CI: 1.26, 3.55%) of fetal CHD cases were attributable to ECEs during the embryonic period. Our findings emphasize the need to pay more attention to pregnant women whose embryonic period falls during the cold season to reduce cold spell detriments to newborns.
摘要：
在过去的十年里，极端温度事件变得更加频繁和持续时间更长。先前关于极端寒冷事件（ECE）与先天性心脏病（CHD）之间关联的研究很少且不一致。我们在中国26个省的1313家医院进行了一项全国性多中心研究，从2013年到2021年共收集了14808名高CHD风险参与者。我们评估了每个孕妇在胚胎期（3-8周）经历的ECE。结果表明，孕妇在胚胎期经历的ECE与胎儿CHD的发展有关，并且与一些特定的胎儿CHD亚型密切相关。如肺动脉狭窄，肺动脉闭锁,和法洛四联症.冠心病的负担，2.21%(95%CI:1.43,2.99%)-2.40%(95%CI:1.26,3.55%)的胎儿CHD病例可归因于胚胎期的ECE。我们的研究结果强调，需要更加关注胚胎期在寒冷季节下降的孕妇，以减少对新生儿的寒流伤害。
