Abstract：
UNASSIGNED: To explore the relationships among the epithelial to mesenchymal transition (EMT)-related factors (SNAIL, TWIST, and E-Cadherin) and clinicopathological parameters and gastric mesangial tumor deposits (TDs) in advanced gastric cancer (AGC) patients and their value in gastric cancer prognosis judgment.
UNASSIGNED: The data of 190 patients who underwent radical resection of ACG were analyzed retrospectively, including 75 cases of TDs (+) and 115 cases of TDs (-). The expression of EMT-related transforming factors Snail, Twist, and E-cadherin in the primary tumor, paracancerous normal tissues, and TDs was detected by immunohistochemistry.
UNASSIGNED: SNAIL and TWIST were overexpressed in primary tumors and TDs, whereas E-Cadherin was down-expressed in primary tumors. SNAIL was correlated significantly with tumor differentiation, lymph node metastases, and TDs (P < 0.05); TWIST was correlated strongly with tumor location, lymph node metastases, and TDs (P < 0.05); E-Cadherin was correlated closely with tumor differentiation and lymph node metastases (P < 0.05). Kaplan-Meier curves showed that SNAIL expression was correlated with DFS (P < 0.05), and TWIST expression was correlated with OS (P < 0.05). Tumor differentiation, lymph node metastasis, and TWIST expression were prognostic-independent risk factors of AGC patients (P < 0.05).
UNASSIGNED: The occurrence and development of gastric cancer and the formation of TDs may be related to EMT, analyzing the expression of EMT-related transforming proteins may be helpful to judge the prognosis of gastric cancer.
UNASSIGNED: The data of 190 patients who underwent radical resection of ACG were analyzed retrospectively, including 75 cases of TDs (+) and 115 cases of TDs (-). The expression of EMT-related transforming factors Snail, Twist, and E-cadherin in the primary tumor, paracancerous normal tissues, and TDs was detected by immunohistochemistry.
UNASSIGNED: SNAIL and TWIST were overexpressed in primary tumors and TDs, whereas E-Cadherin was down-expressed in primary tumors. SNAIL was correlated significantly with tumor differentiation, lymph node metastases, and TDs (P < 0.05); TWIST was correlated strongly with tumor location, lymph node metastases, and TDs (P < 0.05); E-Cadherin was correlated closely with tumor differentiation and lymph node metastases (P < 0.05). Kaplan-Meier curves showed that SNAIL expression was correlated with DFS (P < 0.05), and TWIST expression was correlated with OS (P < 0.05). Tumor differentiation, lymph node metastasis, and TWIST expression were prognostic-independent risk factors of AGC patients (P < 0.05).
UNASSIGNED: The occurrence and development of gastric cancer and the formation of TDs may be related to EMT, analyzing the expression of EMT-related transforming proteins may be helpful to judge the prognosis of gastric cancer.
摘要：
■探讨上皮间质转化（EMT）相关因子（SNAIL，扭曲,和E-Cadherin）和晚期胃癌（AGC）患者的临床病理参数和胃系膜肿瘤沉积物（TD）及其在胃癌预后判断中的价值。
■对190例接受ACG根治术的患者资料进行回顾性分析，其中TDs(+)75例,TDs(-)115例。EMT相关转化因子Snail的表达,Twist,和原发性肿瘤中的E-cadherin，癌旁正常组织，免疫组织化学检测TDs。
■SNAIL和TWIST在原发性肿瘤和TDs中过表达，而E-Cadherin在原发性肿瘤中低表达。SNAIL与肿瘤分化程度显著相关,淋巴结转移,和TDs（P<0.05）；TWIST与肿瘤位置密切相关，淋巴结转移,E-Cadherin与肿瘤分化程度和淋巴结转移密切相关(P<0.05)。Kaplan-Meier曲线显示SNAIL表达与DFS相关(P<0.05),TWIST表达与OS相关(P<0.05)。肿瘤分化,淋巴结转移,TWIST表达是AGC患者预后的独立危险因素(P<0.05)。
■胃癌的发生发展和TDs的形成可能与EMT有关，分析EMT相关转化蛋白的表达可能有助于判断胃癌的预后。
■对190例接受ACG根治术的患者资料进行回顾性分析，其中TDs(+)75例,TDs(-)115例。EMT相关转化因子Snail的表达,Twist,和原发性肿瘤中的E-cadherin，癌旁正常组织，免疫组织化学检测TDs。
■SNAIL和TWIST在原发性肿瘤和TDs中过表达，而E-Cadherin在原发性肿瘤中低表达。SNAIL与肿瘤分化程度显著相关,淋巴结转移,和TDs（P<0.05）；TWIST与肿瘤位置密切相关，淋巴结转移,E-Cadherin与肿瘤分化程度和淋巴结转移密切相关(P<0.05)。Kaplan-Meier曲线显示SNAIL表达与DFS相关(P<0.05),TWIST表达与OS相关(P<0.05)。肿瘤分化,淋巴结转移,TWIST表达是AGC患者预后的独立危险因素(P<0.05)。
■胃癌的发生发展和TDs的形成可能与EMT有关，分析EMT相关转化蛋白的表达可能有助于判断胃癌的预后。
