PDF(Pubmed)
Abstract：
Postoperative cognitive dysfunction (POCD) commonly occurs after surgery, particularly in elderly individuals. It is characterized by a notable decline in cognitive performance, encompassing memory, attention, coordination, orientation, verbal fluency, and executive function. This reduction in cognitive abilities contributes to extended hospital stays and heightened mortality. The prevalence of POCD can reach 40% within 1 week following cardiovascular surgery and remains as high as 17% 3 months post-surgery. Furthermore, POCD exacerbates the long-term risk of Alzheimer\'s disease (AD). As a result, numerous studies have been conducted to investigate the molecular mechanisms underlying POCD and potential preventive strategies. This article provides a review of the research progress on POCD.
摘要：
术后认知功能障碍（POCD）通常发生在手术后，尤其是老年人。它的特点是认知能力显著下降，包含记忆，注意,协调,定位,口语流利,和执行功能。认知能力的这种降低有助于延长住院时间和增加死亡率。POCD的患病率在心血管手术后1周内可以达到40％，术后3个月仍高达17％。此外，POCD加重阿尔茨海默病(AD)的长期风险。因此,已经进行了许多研究来研究POCD的分子机制和潜在的预防策略。本文就POCD的研究进展作一综述。
