PDF(Pubmed)
Abstract：
OBJECTIVE: To determine the locations on the 24-2 visual field (VF) testing grid that are most likely to progress in patients with ocular hypertension (OHTN). Based on a structural model of superior and inferior areas of relative vulnerability at the optic disc, we hypothesized that the nasal and paracentral regions are more prone to show a reduction in sensitivity.
METHODS: Posthoc analysis of data collected in phases 1 and 2 of the Ocular Hypertension Treatment Study (OHTS). A pointwise analysis was applied to determine the progression patterns in the early and delayed treatment groups. Each group\'s progression rate and frequency were calculated for each of the 52 locations corresponding to the 24-2 VF strategy, using trend- and event-based analyses, respectively.
RESULTS: For the event-based analysis, the events were most commonly found in the nasal and paracentral regions. The same regions, with some modest variation, were found to have the fastest rates of progression (ROP) measured with trend analysis. A similar pattern of progression was observed in both the early and delayed treatment groups. The difference in event rates and ROP between the early and delayed treatment groups was also greatest in the nasal and paracentral regions.
CONCLUSIONS: Development of VF loss in ocular hypertensive eyes appears to be consistent with the vulnerability zones previously described in glaucomatous eyes with established VF loss. Ocular hypotensive treatment likely helps to slow the rate of progression in these regions. This suggests that careful monitoring of these locations may be useful.
METHODS: Posthoc analysis of data collected in phases 1 and 2 of the Ocular Hypertension Treatment Study (OHTS). A pointwise analysis was applied to determine the progression patterns in the early and delayed treatment groups. Each group\'s progression rate and frequency were calculated for each of the 52 locations corresponding to the 24-2 VF strategy, using trend- and event-based analyses, respectively.
RESULTS: For the event-based analysis, the events were most commonly found in the nasal and paracentral regions. The same regions, with some modest variation, were found to have the fastest rates of progression (ROP) measured with trend analysis. A similar pattern of progression was observed in both the early and delayed treatment groups. The difference in event rates and ROP between the early and delayed treatment groups was also greatest in the nasal and paracentral regions.
CONCLUSIONS: Development of VF loss in ocular hypertensive eyes appears to be consistent with the vulnerability zones previously described in glaucomatous eyes with established VF loss. Ocular hypotensive treatment likely helps to slow the rate of progression in these regions. This suggests that careful monitoring of these locations may be useful.
摘要：
目的：确定24-2视野（VF）测试网格上最有可能在高眼压（OHTN）患者中进展的位置。根据视盘上相对脆弱区域的结构模型，我们假设鼻部和中央旁区域更容易显示敏感性降低.
方法：对眼部高血压治疗研究（OHTS）的1期和2期收集的数据进行事后分析。应用逐点分析来确定早期和延迟治疗组的进展模式。每个组的进展率和频率计算52个位置对应的24-2VF策略，使用基于趋势和事件的分析，分别。
结果：对于基于事件的分析，这些事件最常见于鼻部和中央旁区域.同样的地区,有一些适度的变化，被发现有最快的进展率（ROP）测量的趋势分析。在早期和延迟治疗组中观察到相似的进展模式。早期和延迟治疗组之间的事件发生率和ROP差异在鼻部和中央旁区域也最大。
结论：高眼压眼VF丧失的发展似乎与先前在已确定VF丧失的青光眼中描述的脆弱区一致。眼部低血压治疗可能有助于减缓这些区域的进展速度。这表明仔细监测这些位置可能是有用的。
方法：对眼部高血压治疗研究（OHTS）的1期和2期收集的数据进行事后分析。应用逐点分析来确定早期和延迟治疗组的进展模式。每个组的进展率和频率计算52个位置对应的24-2VF策略，使用基于趋势和事件的分析，分别。
结果：对于基于事件的分析，这些事件最常见于鼻部和中央旁区域.同样的地区,有一些适度的变化，被发现有最快的进展率（ROP）测量的趋势分析。在早期和延迟治疗组中观察到相似的进展模式。早期和延迟治疗组之间的事件发生率和ROP差异在鼻部和中央旁区域也最大。
结论：高眼压眼VF丧失的发展似乎与先前在已确定VF丧失的青光眼中描述的脆弱区一致。眼部低血压治疗可能有助于减缓这些区域的进展速度。这表明仔细监测这些位置可能是有用的。
