关键词: Biomedical applications Electrospinning Green solvents Natural polymers Polymer nanofibers Sustainability

Mesh : Nanofibers / chemistry Humans Tissue Engineering / methods Biocompatible Materials / chemistry Polymers / chemistry Green Chemistry Technology / methods Drug Delivery Systems Animals

来  源:   DOI:10.1016/j.ijbiomac.2024.130135

Abstract:
Electrospinning is the simplest technique to produce ultrathin nanofibers, which enables the use of nanotechnology in various applications. Nanofibrous materials produced through electrospinning have garnered significant attention in biomedical applications due to their unique properties and versatile potential. In recent years, there has been a growing emphasis on incorporating sustainability principles into material design and production. However, electrospun nanofibers, owing to their reliance on solvents associated with significant drawbacks like toxicity, flammability, and disposal challenges, frequently fall short of meeting environmentally friendly standards. Due to the limited solvent choices and heightened concerns for safety and hygiene in modern living, it becomes imperative to carefully assess the implications of employing electrospun nanofibers in diverse applications and consumer products. This systematic review aims to comprehensively assess the current state of research and development in the field of \"green and natural\" electrospun polymer nanofibers as well as more fascinating and eco-friendly commercial techniques, solvent preferences, and other green routes that respect social and legal restrictions tailored for biomedical applications. We explore the utilization of biocompatible and biodegradable polymers sourced from renewable feedstocks, eco-friendly processing techniques, and the evaluation of environmental impacts. Our review highlights the potential of green and natural electrospun nanofibers to address sustainability concerns while meeting the demanding requirements of various biomedical applications, including tissue engineering, drug delivery, wound healing, and diagnostic platforms. We analyze the advantages, challenges, and future prospects of these materials, offering insights into the evolving landscape of environmentally responsible nanofiber technology in the biomedical field.
摘要:
静电纺丝是生产超薄纳米纤维的最简单技术,这使得纳米技术能够在各种应用中使用。通过静电纺丝生产的纳米纤维材料由于其独特的性能和用途潜力而在生物医学应用中引起了极大的关注。近年来,人们越来越重视将可持续性原则纳入材料设计和生产。然而,静电纺纳米纤维,由于它们依赖与毒性等重大缺点相关的溶剂,可燃性,和处置挑战,经常达不到环保标准。由于溶剂选择有限,以及现代生活中对安全和卫生的高度关注,必须仔细评估在各种应用和消费产品中使用电纺纳米纤维的影响。这篇系统的综述旨在全面评估“绿色和天然”电纺聚合物纳米纤维以及更迷人和环保的商业技术领域的研究和开发现状,溶剂偏好,和其他绿色路线,尊重为生物医学应用量身定制的社会和法律限制。我们探索了来自可再生原料的生物相容性和可生物降解聚合物的利用,环保加工技术,和环境影响评估。我们的评论强调了绿色和天然电纺纳米纤维在满足各种生物医学应用的苛刻要求的同时解决可持续性问题的潜力。包括组织工程,药物输送,伤口愈合,诊断平台。我们分析了优势,挑战,以及这些材料的未来前景,提供对生物医学领域环境负责的纳米纤维技术不断发展的见解。
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