在幼稚 T 细胞激活期间通过 CD27 - TRAF2 - SHP - 1 轴的信号传导促进记忆相关基因调控网络。
关键词: CAR-T cell therapy CD27 CD8(+) T cell SHP-1 phosphatase chimeric antigen receptor costimulation memory and effector fate determination naive T cell activation
Mesh : TNF Receptor-Associated Factor 2 / genetics metabolism CD28 Antigens / metabolism Gene Regulatory Networks Signal Transduction Lymphocyte Activation Receptors, Antigen, T-Cell / metabolism Tumor Necrosis Factor Receptor Superfamily, Member 7 / genetics metabolism CD27 Ligand / genetics metabolism CD8-Positive T-Lymphocytes
来 源:
DOI:10.1016/j.immuni.2024.01.011
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