Abstract：
OBJECTIVE: To compare the efficacy of several local antibiotic regimens in preventing surgical site infection (SSI) in clean surgical wounds.
METHODS: The authors searched CNKI (China National Knowledge Infrastructure), the VIP (VIP information resource integration service platform), Wanfang Data knowledge service platform (WANFANG), SinoMed, Cochrane Library, EMBASE, and PubMed.
METHODS: A total of 20 randomized controlled trials published between January 1, 2000 and April 1, 2021 were included in this meta-analysis.
METHODS: Authors extracted the name of the first author, publication date, country, type of surgery, follow-up time, mean age of participants, sample size of each group, interventions, outcome indicators, and study type from each article.
RESULTS: The overall effectiveness of eight local managements in reducing the incidence of the SSI effect were compared through the SUCRA (surface under the cumulative ranking curve) probabilities. The results of a network meta-analysis demonstrated that gentamicin ointment (odds ratio [OR], 0.16; 95% CI, 0.04-0.60), mupirocin ointment (OR, 0.44; 95% CI, 0.21-0.94), and gentamicin soaking of the graft (OR, 0.63; 95% CI, 0.44-0.91) significantly reduced the incidence of SSI compared with control. Further, vancomycin soaking of the graft (86.7%) ranked first, followed by gentamicin ointment (81.1%), gentamicin irrigation (79.9%), mupirocin ointment (56.8%), triple antibiotic ointment (47.8%), gentamicin soaking of the graft (42.3%), and vancomycin powder (22.1%); ampicillin powder (17.8%) was the least effective drug.
CONCLUSIONS: The findings indicate that local antibiotics combined with conventional antibiotics in the wound before wound closure are effective in reducing the incidence of SSI in clean surgical wounds. Vancomycin inoculation of the graft exhibited the best effect.
METHODS: The authors searched CNKI (China National Knowledge Infrastructure), the VIP (VIP information resource integration service platform), Wanfang Data knowledge service platform (WANFANG), SinoMed, Cochrane Library, EMBASE, and PubMed.
METHODS: A total of 20 randomized controlled trials published between January 1, 2000 and April 1, 2021 were included in this meta-analysis.
METHODS: Authors extracted the name of the first author, publication date, country, type of surgery, follow-up time, mean age of participants, sample size of each group, interventions, outcome indicators, and study type from each article.
RESULTS: The overall effectiveness of eight local managements in reducing the incidence of the SSI effect were compared through the SUCRA (surface under the cumulative ranking curve) probabilities. The results of a network meta-analysis demonstrated that gentamicin ointment (odds ratio [OR], 0.16; 95% CI, 0.04-0.60), mupirocin ointment (OR, 0.44; 95% CI, 0.21-0.94), and gentamicin soaking of the graft (OR, 0.63; 95% CI, 0.44-0.91) significantly reduced the incidence of SSI compared with control. Further, vancomycin soaking of the graft (86.7%) ranked first, followed by gentamicin ointment (81.1%), gentamicin irrigation (79.9%), mupirocin ointment (56.8%), triple antibiotic ointment (47.8%), gentamicin soaking of the graft (42.3%), and vancomycin powder (22.1%); ampicillin powder (17.8%) was the least effective drug.
CONCLUSIONS: The findings indicate that local antibiotics combined with conventional antibiotics in the wound before wound closure are effective in reducing the incidence of SSI in clean surgical wounds. Vancomycin inoculation of the graft exhibited the best effect.
摘要：
目的：比较几种局部抗生素方案预防清洁手术伤口手术部位感染（SSI）的效果。
方法：作者检索CNKI(中国国家知识基础设施)，VIP（VIP信息资源整合服务平台），万方数据知识服务平台（万方），SinoMed,科克伦图书馆,EMBASE,和PubMed。
方法：2000年1月1日至2021年4月1日发表的共20项随机对照试验纳入本荟萃分析。
方法：作者提取了第一作者的名字，出版日期,国家,手术类型,随访时间,参与者的平均年龄，每组的样本量，干预措施，结果指标，并从每篇文章中研究类型。
结果：通过SUCRA（累积排序曲线下的表面）概率比较了八种局部管理在降低SSI效应发生率方面的总体有效性。网络荟萃分析的结果表明庆大霉素软膏(比值比[OR]，0.16；95%CI，0.04-0.60），莫匹罗星软膏(或，0.44；95%CI，0.21-0.94），和庆大霉素浸泡移植物(OR，0.63；95％CI，0.44-0.91）与对照组相比显着降低了SSI的发生率。Further,万古霉素浸种者(86.7%)排名第一,其次是庆大霉素软膏（81.1%），庆大霉素灌溉（79.9％），莫匹罗星软膏(56.8%)，三联抗生素软膏（47.8%），移植物的庆大霉素浸泡（42.3％），和万古霉素粉末（22.1％）；氨苄西林粉末（17.8％）是效果最差的药物。
结论：研究结果表明，伤口闭合前在伤口中局部使用抗生素与常规抗生素联合使用可有效降低清洁手术伤口的SSI发生率。万古霉素接种移植物效果最好。
方法：作者检索CNKI(中国国家知识基础设施)，VIP（VIP信息资源整合服务平台），万方数据知识服务平台（万方），SinoMed,科克伦图书馆,EMBASE,和PubMed。
方法：2000年1月1日至2021年4月1日发表的共20项随机对照试验纳入本荟萃分析。
方法：作者提取了第一作者的名字，出版日期,国家,手术类型,随访时间,参与者的平均年龄，每组的样本量，干预措施，结果指标，并从每篇文章中研究类型。
结果：通过SUCRA（累积排序曲线下的表面）概率比较了八种局部管理在降低SSI效应发生率方面的总体有效性。网络荟萃分析的结果表明庆大霉素软膏(比值比[OR]，0.16；95%CI，0.04-0.60），莫匹罗星软膏(或，0.44；95%CI，0.21-0.94），和庆大霉素浸泡移植物(OR，0.63；95％CI，0.44-0.91）与对照组相比显着降低了SSI的发生率。Further,万古霉素浸种者(86.7%)排名第一,其次是庆大霉素软膏（81.1%），庆大霉素灌溉（79.9％），莫匹罗星软膏(56.8%)，三联抗生素软膏（47.8%），移植物的庆大霉素浸泡（42.3％），和万古霉素粉末（22.1％）；氨苄西林粉末（17.8％）是效果最差的药物。
结论：研究结果表明，伤口闭合前在伤口中局部使用抗生素与常规抗生素联合使用可有效降低清洁手术伤口的SSI发生率。万古霉素接种移植物效果最好。
