PDF(Pubmed)
Abstract：
UNASSIGNED: Cognitive decline is a common consequence of aging. Dietary patterns that lack fibers and are high in saturated fats worsen cognitive impairment by triggering pro-inflammatory pathways and metabolic dysfunctions. Emerging evidence highlights the neurocognitive benefits of fiber-rich diets and the crucial role of gut-microbiome-brain signaling. However, the mechanisms of this diet-microbiome-brain regulation remain largely unclear.
UNASSIGNED: Accordingly, we herein investigated the unexplored neuroprotective mechanisms of dietary pulses-derived resistant starch (RS) in improving aging-associated neurocognitive function in an aged (60-weeks old) murine model carrying a human microbiome.
UNASSIGNED: Following 20-weeks dietary regimen which included a western-style diet without (control; CTL) or with 5% w/w fortification with RS from pinto beans (PTB), black-eyed-peas (BEP), lentils (LEN), chickpeas (CKP), or inulin fiber (INU), we find that RS, particularly from LEN, ameliorate the cognitive impairments induced by western diet. Mechanistically, RS-mediated improvements in neurocognitive assessments are attributed to positive remodeling of the gut microbiome-metabolome arrays, which include increased short-chain fatty acids and reduced branched-chain amino acids levels. This microbiome-metabolite-brain signaling cascade represses neuroinflammation, cellular senescence, and serum leptin/insulin levels, while enhancing lipid metabolism through improved hepatic function. Altogether, the data demonstrate the prebiotic effects of RS in improving neurocognitive function via modulating the gut-brain axis.
UNASSIGNED: Accordingly, we herein investigated the unexplored neuroprotective mechanisms of dietary pulses-derived resistant starch (RS) in improving aging-associated neurocognitive function in an aged (60-weeks old) murine model carrying a human microbiome.
UNASSIGNED: Following 20-weeks dietary regimen which included a western-style diet without (control; CTL) or with 5% w/w fortification with RS from pinto beans (PTB), black-eyed-peas (BEP), lentils (LEN), chickpeas (CKP), or inulin fiber (INU), we find that RS, particularly from LEN, ameliorate the cognitive impairments induced by western diet. Mechanistically, RS-mediated improvements in neurocognitive assessments are attributed to positive remodeling of the gut microbiome-metabolome arrays, which include increased short-chain fatty acids and reduced branched-chain amino acids levels. This microbiome-metabolite-brain signaling cascade represses neuroinflammation, cellular senescence, and serum leptin/insulin levels, while enhancing lipid metabolism through improved hepatic function. Altogether, the data demonstrate the prebiotic effects of RS in improving neurocognitive function via modulating the gut-brain axis.
摘要：
■认知下降是衰老的常见后果。缺乏纤维和饱和脂肪含量高的饮食模式通过触发促炎途径和代谢功能障碍而使认知障碍恶化。新的证据强调了富含纤维的饮食的神经认知益处以及肠道-微生物组-大脑信号的关键作用。然而,这种饮食-微生物组-大脑调节的机制仍不清楚.
■因此，我们在一个携带人类微生物组的老年(60周龄)小鼠模型中,研究了膳食豆类源性抗性淀粉(RS)在改善衰老相关神经认知功能方面的神经保护机制.
■经过20周的饮食方案，其中包括西式饮食，不含（对照；CTL）或5％w/w强化来自pintobean（PTB）的RS，黑眼豌豆(BEP),扁豆（LEN），鹰嘴豆（CKP），或菊粉纤维(INU)，我们发现RS,特别是LEN,改善西方饮食引起的认知障碍。机械上,RS介导的神经认知评估的改善归因于肠道微生物组-代谢组阵列的正重塑。其中包括增加的短链脂肪酸和降低的支链氨基酸水平。这种微生物组-代谢物-大脑信号级联抑制神经炎症，细胞衰老,和血清瘦素/胰岛素水平，同时通过改善肝功能增强脂质代谢。总之,数据表明RS通过调节肠-脑轴改善神经认知功能的益生元效应。
■因此，我们在一个携带人类微生物组的老年(60周龄)小鼠模型中,研究了膳食豆类源性抗性淀粉(RS)在改善衰老相关神经认知功能方面的神经保护机制.
■经过20周的饮食方案，其中包括西式饮食，不含（对照；CTL）或5％w/w强化来自pintobean（PTB）的RS，黑眼豌豆(BEP),扁豆（LEN），鹰嘴豆（CKP），或菊粉纤维(INU)，我们发现RS,特别是LEN,改善西方饮食引起的认知障碍。机械上,RS介导的神经认知评估的改善归因于肠道微生物组-代谢组阵列的正重塑。其中包括增加的短链脂肪酸和降低的支链氨基酸水平。这种微生物组-代谢物-大脑信号级联抑制神经炎症，细胞衰老,和血清瘦素/胰岛素水平，同时通过改善肝功能增强脂质代谢。总之,数据表明RS通过调节肠-脑轴改善神经认知功能的益生元效应。
