UNASSIGNED: Accordingly, we herein investigated the unexplored neuroprotective mechanisms of dietary pulses-derived resistant starch (RS) in improving aging-associated neurocognitive function in an aged (60-weeks old) murine model carrying a human microbiome.
UNASSIGNED: Following 20-weeks dietary regimen which included a western-style diet without (control; CTL) or with 5% w/w fortification with RS from pinto beans (PTB), black-eyed-peas (BEP), lentils (LEN), chickpeas (CKP), or inulin fiber (INU), we find that RS, particularly from LEN, ameliorate the cognitive impairments induced by western diet. Mechanistically, RS-mediated improvements in neurocognitive assessments are attributed to positive remodeling of the gut microbiome-metabolome arrays, which include increased short-chain fatty acids and reduced branched-chain amino acids levels. This microbiome-metabolite-brain signaling cascade represses neuroinflammation, cellular senescence, and serum leptin/insulin levels, while enhancing lipid metabolism through improved hepatic function. Altogether, the data demonstrate the prebiotic effects of RS in improving neurocognitive function via modulating the gut-brain axis.
■因此,我们在一个携带人类微生物组的老年(60周龄)小鼠模型中,研究了膳食豆类源性抗性淀粉(RS)在改善衰老相关神经认知功能方面的神经保护机制.
■经过20周的饮食方案,其中包括西式饮食,不含(对照;CTL)或5%w/w强化来自pintobean(PTB)的RS,黑眼豌豆(BEP),扁豆(LEN),鹰嘴豆(CKP),或菊粉纤维(INU),我们发现RS,特别是LEN,改善西方饮食引起的认知障碍。机械上,RS介导的神经认知评估的改善归因于肠道微生物组-代谢组阵列的正重塑。其中包括增加的短链脂肪酸和降低的支链氨基酸水平。这种微生物组-代谢物-大脑信号级联抑制神经炎症,细胞衰老,和血清瘦素/胰岛素水平,同时通过改善肝功能增强脂质代谢。总之,数据表明RS通过调节肠-脑轴改善神经认知功能的益生元效应。