关键词: Aneurysmal fibrous histiocytoma Midostaurin Pazopanib Protein kinase C inhibitor Radiation

来  源:   DOI:10.1159/000511073   PDF(Pubmed)

Abstract:
Aneurysmal fibrous histiocytoma (AFH) is a rare variant of cutaneous fibrous histiocytoma, with low malignant potential and infrequent metastatic progression. We present the case of a 19-year-old female with a large AFH of the neck metastatic to soft tissue and treated with radiation therapy and molecularly targeted therapy. To our knowledge, this is the first report describing either radiation therapy and palliation or the use of targeted therapy in this uncommon malignancy and can provide insight into future therapeutic strategies.
摘要:
动脉瘤性纤维组织细胞瘤(AFH)是皮肤纤维组织细胞瘤的一种罕见变体,具有低恶性潜能和罕见的转移性进展。我们介绍了一名19岁的女性,其颈部的AFH大转移到软组织,并接受了放射治疗和分子靶向治疗。据我们所知,这是第一份报告,描述了放疗和姑息治疗或靶向治疗在这一罕见恶性肿瘤中的应用,可以为未来的治疗策略提供见解.
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