METHODS: We searched PubMed and Web of Science electronic databases using \"lipocalin-2, diabetic retinopathy, retinal degeneration, diabetic microangiopathies, diabetic neuropathy and inflammation\" as subject terms.
RESULTS: In diabetic retinal neuropathy, LCN2 causes impaired retinal photoreceptor function and retinal neurons; in retinal microangiopathy, LCN2 induces apoptosis of retinal vascular endothelial cells and promotes angiogenesis; in retinal inflammation, increased secretion of LCN2 recruits inflammatory cells and induces pro-inflammatory cytokines. Moreover, LCN2 has the potential as a biomarker for DR. Recent studies have shown that retinal damage can be attenuated by silencing LCN2, which may be associated with the inhibition of caspase-1-mediated pyroptosis, and LCN2 may be a new target for the treatment of DR.
CONCLUSIONS: In conclusion, LCN2, involved in the development of diabetic retinopathy, is a key factor in diabetic retinal microangiopathy, neurodegeneration, and retinal inflammation. LCN2 is likely to be a novel molecular target leading to DR, and a more in-depth study of the pathogenesis of DR caused by LCN2 may provide considerable benefits for clinical research and potential drug development.
方法:我们使用“脂质运载蛋白-2,糖尿病性视网膜病变,视网膜变性,糖尿病微血管病变,糖尿病神经病变和炎症“作为主题词。
结果:在糖尿病性视网膜神经病中,LCN2导致视网膜光感受器功能和视网膜神经元受损;在视网膜微血管病中,LCN2诱导视网膜血管内皮细胞凋亡并促进血管生成;在视网膜炎症中,LCN2分泌增加募集炎性细胞并诱导促炎细胞因子。此外,LCN2具有作为DR生物标志物的潜力。最近的研究表明,沉默LCN2可以减轻视网膜损伤,这可能与抑制caspase-1介导的焦亡有关,LCN2可能是治疗DR的新靶点。
结论:结论:LCN2参与糖尿病视网膜病变的发展,是糖尿病视网膜微血管病变的关键因素,神经变性,和视网膜炎症。LCN2可能是导致DR的新分子靶标,而更深入地研究LCN2引起的DR的发病机制可能为临床研究和潜在药物开发提供可观的益处。