PDF(Pubmed)
Abstract：
OBJECTIVE: This study aimed to investigate the incidence of meibomian gland dysfunction (MGD) in postmenopausal women with primary acquired nasolacrimal duct obstruction (PANDO) and enables ophthalmologists to pay attention to ocular surface damage before surgery.
METHODS: 165 postmenopausal women with PANDO and 115 postmenopausal women with a normal lacrimal drainage system were enrolled in this prospective study. Based on the results of lacrimal duct irrigation and age, the participants were further subdivided. The incidence of different severities of MGD in different groups was calculated and analyzed by the chi-squared test.
RESULTS: The incidence of MGD in the PANDO group was 81.21%, and in the control group, it was 46.96%, which was significantly higher in the presence of PANDO (p < 0.001). The incidence of severe MGD in the complete and incomplete PANDO groups was higher than that in the control group (all p < 0.05), and no significant differences were observed between the complete and incomplete PANDO groups. The incidence of moderate MGD was significantly higher in the complete PANDO group than in the control group (p < 0.001). When age was considered an independent variable, the results revealed a significant value for patients aged < 70 years (p < 0.001).
CONCLUSIONS: Our study revealed a prodominantly high incidence of MGD in postmenopausal women with PANDO, especially in a complete PANDO or aged < 70 years. Ophthalmologists need to pay close attention to MGD in postmenopausal women with PANDO.
METHODS: 165 postmenopausal women with PANDO and 115 postmenopausal women with a normal lacrimal drainage system were enrolled in this prospective study. Based on the results of lacrimal duct irrigation and age, the participants were further subdivided. The incidence of different severities of MGD in different groups was calculated and analyzed by the chi-squared test.
RESULTS: The incidence of MGD in the PANDO group was 81.21%, and in the control group, it was 46.96%, which was significantly higher in the presence of PANDO (p < 0.001). The incidence of severe MGD in the complete and incomplete PANDO groups was higher than that in the control group (all p < 0.05), and no significant differences were observed between the complete and incomplete PANDO groups. The incidence of moderate MGD was significantly higher in the complete PANDO group than in the control group (p < 0.001). When age was considered an independent variable, the results revealed a significant value for patients aged < 70 years (p < 0.001).
CONCLUSIONS: Our study revealed a prodominantly high incidence of MGD in postmenopausal women with PANDO, especially in a complete PANDO or aged < 70 years. Ophthalmologists need to pay close attention to MGD in postmenopausal women with PANDO.
摘要：
目的：本研究旨在探讨原发性获得性鼻泪管阻塞（PANDO）的绝经后妇女睑板腺功能障碍（MGD）的发生率，并使眼科医生在手术前注意眼表损伤。
方法：本前瞻性研究纳入了165例PANDO绝经后妇女和115例泪道引流系统正常的绝经后妇女。根据泪道冲洗的结果和年龄，参与者被进一步细分。通过卡方检验计算并分析不同组不同严重度MGD的发生率。
结果：PANDO组MGD的发生率为81.21%，在对照组中，是46.96%,在PANDO存在下显著更高(p<0.001)。完全和不完全PANDO组的重度MGD发生率均高于对照组(均p<0.05),完全和不完全PANDO组之间没有观察到显著差异。完全PANDO组中度MGD的发生率明显高于对照组(p<0.001)。当年龄被认为是自变量时，结果显示,年龄<70岁的患者具有显著价值(p<0.001).
结论：我们的研究表明，绝经后PANDO妇女MGD的发病率明显较高，尤其是在一个完整的PANDO或年龄<70岁。眼科医生需要密切关注绝经后PANDO妇女的MGD。
方法：本前瞻性研究纳入了165例PANDO绝经后妇女和115例泪道引流系统正常的绝经后妇女。根据泪道冲洗的结果和年龄，参与者被进一步细分。通过卡方检验计算并分析不同组不同严重度MGD的发生率。
结果：PANDO组MGD的发生率为81.21%，在对照组中，是46.96%,在PANDO存在下显著更高(p<0.001)。完全和不完全PANDO组的重度MGD发生率均高于对照组(均p<0.05),完全和不完全PANDO组之间没有观察到显著差异。完全PANDO组中度MGD的发生率明显高于对照组(p<0.001)。当年龄被认为是自变量时，结果显示,年龄<70岁的患者具有显著价值(p<0.001).
结论：我们的研究表明，绝经后PANDO妇女MGD的发病率明显较高，尤其是在一个完整的PANDO或年龄<70岁。眼科医生需要密切关注绝经后PANDO妇女的MGD。
