Abstract：
<b><br>Introduction:</b> Gastroesophageal reflux (GERD) is one of the most common disorders of the alimentary tract. Apart from troublesome symptoms, untreated GERD can lead to Barrett\'s esophagus and, as a consequence, esophageal adenocarcinoma. As for now, the most common treatment of GERD is PPI pharmacotherapy. However, in a number of cases, this treatment is not sufficient or the patient does not tolerate PPI-group drugs. In such cases, interventional therapy is recommended. So far, laparoscopic fundoplication has been the only suggested option. Other, minimally invasive procedures such as Stretta, MUSE, TIFF, or EsophyX were not recommended due to the lack of clinical data. In 2014, Professor H.Inoue from the Digestive Diseases Center, Showa University in Japan reported on the first series of novel, endoscopic, anti-reflux procedures: anti-reflux mucosectomy (ARMS) and anti-reflux mucosal ablation (ARMA).</br> <b><br>Methods:</b> We conducted our prospective, single-center study in 30 patients (14 female, 16 male) with PPI-refractory GERD. All patients underwent FSSG and GERD-HRQL evaluation and GE junction pressure study prior, 6 weeks and 6 months after the procedures. After the procedure, all patients received PPI treatment for 4 weeks.</br> <b><br>Results:</b> We successfully completed the procedures in all 30 patients. The mean procedure time was 42 minutes. No complications occurred. In 86.67% (26) of our patients, we achieved total remission of GERD symptoms, FSSG scores < 6 and GERD-HRQL scores < 8.</br> <b><br>Conclusions:</b> The results of our study show that ARMS and ARMA are simple, safe, improve GERD-related symptoms, and restore the GE junction\'s anti-reflux capacity.</br>.
摘要：
<b>br>简介：</b>胃食管反流（GERD）是消化道最常见的疾病之一。除了麻烦的症状，未经治疗的GERD可导致Barrett食管,因此，食管腺癌。就目前而言,GERD最常见的治疗方法是PPI药物治疗.然而,在许多情况下，这种治疗不充分或患者不能耐受PPI组药物.在这种情况下,建议进行介入治疗。到目前为止,腹腔镜胃底折叠术是唯一的建议选择。Other,微创手术，如Stretta，MUSE,TIFF,由于缺乏临床数据，不推荐使用EsphyX。2014年，消化疾病中心的H.Inoue教授，日本昭和大学第一套系列小说报道，内窥镜,抗反流手术：抗反流粘膜切除术（ARMS）和抗反流粘膜消融（ARMA）。</br><b><br>方法：30名患者的单中心研究(14名女性，16名男性）患有PPI难治性GERD。所有患者均接受FSSG和GERD-HRQL评估以及GE交界处压力研究，手术后6周和6个月。手术后,所有患者接受PPI治疗4周.</br><b><br>结果：</b>我们成功完成了所有30名患者的手术。平均手术时间为42分钟。无并发症发生。在86.67%（26）的患者中，我们实现了GERD症状的完全缓解，FSSG评分<6和GERD-HRQL评分<8。</br><b>br>结论：安全,改善GERD相关症状，并恢复GE接头的抗反流能力。</br>.
