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Abstract：
Quetiapine, a pharmacological agent within the class of atypical antipsychotics, is characterized by its efficacy in mood stabilization and its role in the modulation of serotonergic and dopaminergic pathways. Its therapeutic utility is broad, encompassing the management of acute psychotic episodes, schizophrenia, bipolar disorder, and treatment-resistant depressive states. Quetiapine\'s effectiveness extends to depressive disorders that do not exhibit classic psychotic features, with a side effect profile that is less burdensome than many alternative psychotropic medications. Its versatility in addressing a range of psychiatric conditions is useful in the psychopharmacological management of mood and thought disorders. However, like all drugs, quetiapine may have different effects relative to the individual. It is imperative to approach the administration of quetiapine carefully, ensuring any adverse effects are ameliorated for beneficial therapeutic outcomes. In this case report, we present a psychosis-naive 42-year-old male who developed psychotic symptoms after beginning a quetiapine regimen in order to manage major depressive disorder with suicidal ideation. Clinical suspicion of quetiapine-induced psychosis was a diagnosis considered due to symptom remission secondary to ziprasidone in the place of quetiapine. The determination of a suspected adverse drug reaction can utilize the Naranjo scale to demonstrate the likelihood of an adverse drug reaction. This patient scored a three on the Naranjo scale, indicating a possible adverse effect from quetiapine. Other potential etiologies of psychosis include medication-induced psychosis, major depressive disorder exacerbation, cocaine use/withdrawal, and brief psychotic disorder. Quetiapine-induced psychosis has not been described in the current literature, and therefore, this case report is solely based on clinical evaluation and is intended for educational purposes due to possible confounding factors and etiologies.
摘要：
喹硫平,非典型抗精神病药中的一种药物，其特征在于其在情绪稳定方面的功效及其在调节5-羟色胺能和多巴胺能途径中的作用。其治疗用途广泛，包括急性精神病发作的管理，精神分裂症,双相情感障碍,和抗治疗的抑郁状态。喹硫平的有效性延伸到不表现出经典精神病特征的抑郁症。副作用比许多替代精神药物负担更轻。它在解决一系列精神疾病方面的多功能性可用于情绪和思维障碍的精神药理学管理。然而,像所有的药物一样，喹硫平可能对个体有不同的影响。必须谨慎对待喹硫平的管理，确保任何不良反应得到改善，以获得有益的治疗结果。在这个案例报告中,我们介绍了一名42岁初治精神病的男性,他在开始喹硫平治疗后出现了精神病性症状,以治疗有自杀意念的重度抑郁症.临床怀疑喹硫平引起的精神病是由于齐拉西酮替代喹硫平继发的症状缓解而考虑的诊断。可疑药物不良反应的确定可以利用Naranjo量表来证明药物不良反应的可能性。这个病人在Naranjo量表上得了3分,表明喹硫平可能有不良反应。精神病的其他潜在病因包括药物诱发的精神病，重度抑郁症恶化，可卡因的使用/戒断，和短暂的精神病。喹硫平引起的精神病在目前的文献中没有描述，因此,本病例报告仅基于临床评估,由于可能的混杂因素和病因,本病例报告旨在用于教育目的.
