PDF(Pubmed)
Abstract：
The spice turmeric, which has the Latin name Curcuma longa (C. longa), has various physiological effects. This study evaluated the effects of a hot water mixture with supercritical carbon dioxide C. longa extracts, CLE, and the potential active components of C. longa, turmeronols A and B and bisacurone on inflammation and glucose metabolism. First, we investigated the effect of CLE and the potential active components of C. longa on lipopolysaccharide-induced inflammation in RAW264.7 macrophages. We found a significant decrease in the production of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and nitric oxide with CLE, turmeronol A, and bisacurone, Significant inhibition of each of these substances was also observed, except for TNF-α with turmeronol B. The second part of our work was a 12-week randomized, double-blind, placebo-controlled study in healthy but borderline adults aged 40 to 69 years with overweight and normal/prediabetes glycemia. We compared blood inflammatory and glycometabolic markers in the CLE (n = 55) and placebo groups (n = 55). We found significantly lower serum high-sensitivity C-reactive protein and hemoglobin A1c levels in the CLE group. This group also showed significant improvements in postprandial hyperglycemia and insulin sensitivity indices. Our findings indicate that CLE may reduce low-grade inflammation and thus improve insulin sensitivity and postprandial hyperglycemia. Clinical trial registration: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000051492, UMIN-CTR, UMIN000045106.
摘要：
香料姜黄，它的拉丁名字是姜黄（C.龙骨)，具有各种生理效应。这项研究评估了热水混合物与超临界二氧化碳C.longa提取物的作用，CLE,和C.longa的潜在活性成分，葛根素A和B和比沙酮对炎症和葡萄糖代谢的影响。首先,我们研究了CLE和C.longa的潜在活性成分对脂多糖诱导的RAW264.7巨噬细胞炎症的影响。我们发现白细胞介素（IL）-1β的产生显着减少，IL-6,肿瘤坏死因子(TNF)-α,和一氧化氮与CLE，TurmeronolA,和bisacurone,还观察到这些物质中的每一种的显著抑制,除了TNF-α与姜黄酚B。我们的工作的第二部分是一个为期12周的随机，双盲,在40至69岁超重和正常/糖尿病前期血糖的健康但临界成年人中进行安慰剂对照研究。我们比较了CLE（n=55）和安慰剂组（n=55）的血液炎症和糖代谢标志物。我们发现CLE组的血清高敏C反应蛋白和血红蛋白A1c水平显着降低。该组还显示餐后高血糖和胰岛素敏感性指数的显着改善。我们的研究结果表明，CLE可以减少低度炎症，从而改善胰岛素敏感性和餐后高血糖。临床试验注册：https://center6。乌明。AC.jp/cgi-open-bin/ctr/ctr_view。cgi?recptno=R000051492,UMIN-CTR,UMIN000045106。
