Abstract：
OBJECTIVE: Evaluate a prototype dynamic laryngoplasty system (DLPS) in horses; a feasibility study.
METHODS: 7 healthy Standardbred adult horses.
METHODS: This was an in vivo experimental study. Horses had a standing surgical procedure to induce complete laryngeal hemiplegia, which was subsequently treated using the dynamic laryngoplasty system (DLPS). Activation of the DLPS was achieved using an injection port exiting through the skin (n = 2) or a subcutaneous injection port (n = 5). For each horse, endoscopic examinations of the upper respiratory tract were performed preoperatively, intraoperatively, and 7 days postoperatively. Left-to-right quotient ratios calculated during inactivated and activated states were obtained from still images of the rima glottidis acquired during day 7. In 3 horses, the device was intentionally overinflated to evaluate for device failure, and postmortem examinations were performed on day 7. For the remaining 4 horses, upper respiratory tract endoscopy was repeated at 1 month postoperatively, with no subsequent postmortem exam.
RESULTS: No perioperative complications occurred, and the DLPS was effectively delivered in all horses under standing sedation. The left-to-right quotient ratio at day 7 postoperatively could be altered from a resting position of 0.76 (± 0.06) to a maximum of 0.97 (± 0.06; P < .05). The degree of arytenoid abduction could not be significantly altered after 1 month of device implantation, suspected to be due to peri-implant fibrosis. No coughing nor tracheal contamination was observed at all time points or during inflation.
CONCLUSIONS: The ability to alter the degree of abduction at 7 days postoperatively with the DLPS may be beneficial in selective cases.
METHODS: 7 healthy Standardbred adult horses.
METHODS: This was an in vivo experimental study. Horses had a standing surgical procedure to induce complete laryngeal hemiplegia, which was subsequently treated using the dynamic laryngoplasty system (DLPS). Activation of the DLPS was achieved using an injection port exiting through the skin (n = 2) or a subcutaneous injection port (n = 5). For each horse, endoscopic examinations of the upper respiratory tract were performed preoperatively, intraoperatively, and 7 days postoperatively. Left-to-right quotient ratios calculated during inactivated and activated states were obtained from still images of the rima glottidis acquired during day 7. In 3 horses, the device was intentionally overinflated to evaluate for device failure, and postmortem examinations were performed on day 7. For the remaining 4 horses, upper respiratory tract endoscopy was repeated at 1 month postoperatively, with no subsequent postmortem exam.
RESULTS: No perioperative complications occurred, and the DLPS was effectively delivered in all horses under standing sedation. The left-to-right quotient ratio at day 7 postoperatively could be altered from a resting position of 0.76 (± 0.06) to a maximum of 0.97 (± 0.06; P < .05). The degree of arytenoid abduction could not be significantly altered after 1 month of device implantation, suspected to be due to peri-implant fibrosis. No coughing nor tracheal contamination was observed at all time points or during inflation.
CONCLUSIONS: The ability to alter the degree of abduction at 7 days postoperatively with the DLPS may be beneficial in selective cases.
摘要：
目的：评估马的原型动态喉成形术系统（DLPS）；可行性研究。
方法：7种健康的标准成年马。
方法：这是一项体内实验研究。马进行了站立手术以引起完全的喉偏瘫，随后使用动态喉成形术系统（DLPS）进行治疗。使用通过皮肤排出的注射端口(n=2)或皮下注射端口(n=5)实现DLPS的活化。每一匹马,术前进行上呼吸道内镜检查,术中,术后7天。从第7天获取的声门囊的静止图像获得在失活和活化状态期间计算的左右商比率。三匹马，该装置故意过度充气，以评估装置故障，并在第7天进行尸检。剩下的4匹马,术后1个月重复上呼吸道内镜检查,没有随后的验尸。
结果：无围手术期并发症发生，并且DLPS在站立镇静下有效地在所有马匹中递送。术后第7天的左右商比可以从静止位置0.76（±0.06）更改为最大0.97（±0.06；P<0.05）。器械植入1个月后，类软骨外展程度无明显改变，怀疑是由于种植体周围纤维化。在所有时间点或充气期间均未观察到咳嗽或气管污染。
结论：在选择性病例中，DLPS术后7天改变外展程度的能力可能是有益的。
方法：7种健康的标准成年马。
方法：这是一项体内实验研究。马进行了站立手术以引起完全的喉偏瘫，随后使用动态喉成形术系统（DLPS）进行治疗。使用通过皮肤排出的注射端口(n=2)或皮下注射端口(n=5)实现DLPS的活化。每一匹马,术前进行上呼吸道内镜检查,术中,术后7天。从第7天获取的声门囊的静止图像获得在失活和活化状态期间计算的左右商比率。三匹马，该装置故意过度充气，以评估装置故障，并在第7天进行尸检。剩下的4匹马,术后1个月重复上呼吸道内镜检查,没有随后的验尸。
结果：无围手术期并发症发生，并且DLPS在站立镇静下有效地在所有马匹中递送。术后第7天的左右商比可以从静止位置0.76（±0.06）更改为最大0.97（±0.06；P<0.05）。器械植入1个月后，类软骨外展程度无明显改变，怀疑是由于种植体周围纤维化。在所有时间点或充气期间均未观察到咳嗽或气管污染。
结论：在选择性病例中，DLPS术后7天改变外展程度的能力可能是有益的。
