METHODS: We retrospectively reviewed 35 breast cancer lesions in 32 patients who underwent WB SiPM PET/CT in the prone position as preoperative breast cancer examinations from September 2020 to March 2022. In all cases, a 20-mm spherical VOI was placed in the normal mammary gland to measure the mean standardised uptake value (SUVmean) and the standard deviation (SD) of 18F-fluorodeoxyglucose (FDG) uptake. We prepared four types of candidates (SUVmean + 2 SD, SUVmean + 3 SD, 1.5 SUVmean + 2 SD, 1.5 SUVmean + 3 SD) for thresholds for delineating tumor contours on PET images. On the semiautomatic viewer soft, the maximum tumor sizes were measured at each of the four thresholds and compared with the pathological tumor sizes, including the extensive intraductal component (EIC).
RESULTS: The lesion detection sensitivity was 97% for WB SiPM PET. PET detected 34 lesions, excluding 4-mm ductal carcinomas in situ (DCIS). PET measurements at the \'1.5 SUVmean + 2 SD\' threshold demonstrated values closest to the pathological tumor sizes, including EIC. Moreover, \'1.5 SUVmean + 2 SD\' had the highest concordance (63%).
CONCLUSIONS: The study demonstrated that among various PET thresholds, the \'1.5 SUVmean + 2 SD\' threshold exhibited the best performance. However, even with this threshold, the concordance rate was limited to only 63%.
方法:我们回顾性分析了2020年9月至2022年3月在俯卧位行WBSiPMPET/CT术前乳腺癌检查的32例患者的35个乳腺癌病灶。在所有情况下,将20毫米球形VOI置于正常乳腺中,以测量18F-氟代脱氧葡萄糖(FDG)摄取的平均标准化摄取值(SUVmean)和标准偏差(SD).我们准备了四种类型的候选物(SUVmean+2SD,SUVmean+3SD,1.5SUVmean+2SD,1.5SUVmean3SD)用于在PET图像上描绘肿瘤轮廓的阈值。在半自动查看器软,在四个阈值中的每个阈值处测量最大肿瘤大小,并与病理肿瘤大小进行比较,包括广泛的导管内组件(EIC)。
结果:WBSiPMPET的病灶检测灵敏度为97%。PET检测到34个病灶,不包括4毫米导管原位癌(DCIS)。PET测量值在“1.5SUVmean+2SD”阈值下显示的值最接近病理肿瘤大小,包括EIC。此外,“1.5SUVmean+2SD”一致性最高(63%)。
结论:研究表明,在各种PET阈值中,“1.5SUVmean+2SD”阈值表现出最佳性能。然而,即使有了这个门槛,协调率仅限制在63%。