Abstract：
The oral mucosa can be involved in a wide variety of mucocutaneous conditions that may present primarily in the mouth or affect other cutaneous or mucosal sites. Many of these conditions are immune mediated and typically present as inflammatory mucosal pathology. Patients experiencing such conditions usually seek medical evaluation and treatment due to the associated pain and discomfort, and occasionally taste disturbance or dysphagia and the overall deterioration in the oral health-related quality of life. These conditions share some common features and there could be some overlap in their clinical presentation, which can lead to delays in diagnosis and proper management of patients. Clinicians dealing with such disorders, including dermatologists, need to be aware of the oral manifestations of mucocutaneous conditions, their clinical features, underlying mechanisms, diagnostic approaches, and treatment options, as well as the recent advances in the research on these conditions. This review provides a comprehensive, evidence-based reference for clinicians, with updated insights into a group of immune mediated conditions known to cause oral mucosal pathology. Part one will cover oral lichen planus, erythema multiforme and systemic lupus erythematosus, while part two will cover recurrent aphthous stomatitis, pemphigus vulgaris and mucous membrane pemphigoid, in addition to the less common disorders linear IgA disease, dermatitis herpetiformis and epidermolysis bullosa.
摘要：
口腔粘膜可涉及多种粘膜皮肤病症,其可主要存在于口腔中或影响其他皮肤或粘膜部位。这些病症中的许多是免疫介导的并且通常表现为炎性粘膜病理学。由于相关的疼痛和不适，患有此类疾病的患者通常会寻求医学评估和治疗。偶尔会出现味觉障碍或吞咽困难，以及口腔健康相关生活质量的整体恶化。这些情况具有一些共同的特征，并且在临床表现上可能有一些重叠，这可能导致延误诊断和患者的适当管理。处理这种疾病的临床医生，包括皮肤科医生,需要了解皮肤粘膜疾病的口腔表现，他们的临床特征，潜在机制，诊断方法，和治疗选择，以及这些条件研究的最新进展。这篇综述提供了一个全面的，为临床医生提供循证参考，对一组已知引起口腔粘膜病理学的免疫介导性疾病的最新见解。第一部分将涵盖口腔扁平苔藓，多形性红斑和系统性红斑狼疮，而第二部分将涵盖复发性口疮性口炎，寻常型天疱疮和粘膜类天疱疮，除了不太常见的线性IgA疾病，疱疹样皮炎和大疱性表皮松解症。
