UNASSIGNED: This systematic review, follows PRISMA guidelines, included six RCTs from PubMed/MEDLINE, Cochrane Library, Scopus, Web of Science, and CINAHL. Patients with hypospadias repair with use of SDF or DDF were analyzed for outcome, Urethrocutaneous fistula, meatal stenosis, glans dehiscence, penile torsion and cosmetic outcomes. Statistical analysis was done using Review Manager, with TSA and FI ensuring result robustness.
UNASSIGNED: Six studies met inclusion criteria, and risk of bias assessment indicated low risk across all domains. Meta-analysis results favored DDF over SDF for reducing urethrocutaneous fistula (RR 0.37, 95% CI 0.20-0.68) but showed no significant difference in meatal stenosis and glans dehiscence. DDF also associated with lower risk of penile torsion (RR 0.05, 95% CI 0.01-0.35).
UNASSIGNED: The systematic review, based on randomized controlled trials (RCTs), provides evidence supporting the use of DDF over SDF in hypospadias repair, particularly in distal hypospadias using the TIP procedure. The article emphasizes the potential advantages of DDF in reducing UCF but further robust evidence is needed to confirm these results based on the findings of TSA and FI.
■本系统综述,遵循PRISMA准则,包括来自PubMed/MEDLINE的六个RCT,科克伦图书馆,Scopus,WebofScience,和CINAHL。分析使用SDF或DDF修复尿道下裂的患者的结果,尿道皮肤瘘,肉孔狭窄,龟头开裂,阴茎扭转和美容结果。使用ReviewManager进行统计分析,TSA和FI确保结果的鲁棒性。
■六项研究符合纳入标准,偏见风险评估表明,所有领域的风险都很低。Meta分析结果在减少尿道瘘方面,DDF优于SDF(RR0.37,95%CI0.20-0.68),但在食道狭窄和龟裂方面没有显着差异。DDF还与较低的阴茎扭转风险相关(RR0.05,95%CI0.01-0.35)。
■系统综述,基于随机对照试验(RCT),提供证据支持DDF在尿道下裂修复中的使用,特别是在使用TIP程序的远端尿道下裂。文章强调了DDF在减少UCF方面的潜在优势,但需要进一步的有力证据来证实这些结果基于TSA和FI的发现。